ArticleArchives of Razi Institute2025
Effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice.
Article in Archives of Razi Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to determine the effects of exposure to sericin on serum GH, IGF-1 and antioxidant levels following parturition in mice. Forty pregnant female NMRI mice were allocated into four groups. In the control group, pregnant mice were given water as a placebo, whereas pregnant female mice in groups 2-4 were orally administered sericin (112.5, 225, and 450 mg/kg) on different days of gestation (5, 8, 11, 14, and 17). Following parturition, the open field test (OFT), forced swimming test (FST), tail suspension test (TST) and open field tests were used to evaluate depressive-like and antidepressant activity of sericin. At the end of the study, serum growth hormone (GH), insulin-like growth factor-1 (IGF-1), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and total antioxidant status (TAS) levels were determined. According to the results, sericin administration during pregnancy decreased immobility time in FST and TST, and increased the number of crosses in the OFT compared to the control group (P<0.05). Exposure to sericin significantly decreased serum MDA, while it increased SOD, GPx, and TAS levels compared with the control group (P<0.05). Also, sericin exposure during gestation significantly increased serum GH and IGF-1 levels compared to the control group (P<0.05). These results suggested pre-partum administration of sericin has antidepressant effect in postpartum mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.