Evidence map›Paper›PMID 42058186›Full record

ArticleFrontiers in immunology2026

Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway.

Xie Li, Chao Han, Yuemei Yao, Yuanxin Shi, Bin Chen, Yi Xiao, Guohui Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xie Li *Key Laboratory of Oral Diseases Research, School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Chao Han *Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou, China.
Yuemei Yao *Key Laboratory of Oral Diseases Research, School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Yuanxin ShiKey Laboratory of Oral Diseases Research, School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Bin ChenKey Laboratory of Oral Diseases Research, School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Yi XiaoInstitute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou, China.
Guohui BaiKey Laboratory of Oral Diseases Research, School of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral lichen planus (OLP), known as a common and chronic mucosal inflammatory disease. Due to its potential for cancerous transformation, this disease has long been a subject of significant concern. Its pathogenesis is that an unknown antigen activates oral keratinocytes and antigen-presenting cells (APCs) in the epithelium, leading to a T cell-mediated immune response. This study investigates the regulatory role of HIF-1α transcription factor and the potential role of autophagy in a simulated OLP inflammatory cell model. In this study, by comparing the control group with the model group, we observed a notable up-regulation of

Indexed as

AutophagyHypoxia-Inducible Factor 1, alpha SubunitLichen Planus, OralLysosomesAnimalsCaenorhabditis elegansHumansKeratinocytesLipopolysaccharidesPorphyromonas gingivalisSignal TransductionHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitLipopolysaccharidesautophagyHIF-1αlysosomeoral lichen planusPorphyromonas gingivalis lipopolysaccharide

Identifiers

PMID42058186
PMCPMC13121079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.