ArticleFrontiers in bioengineering and biotechnology2026
Standalone methacrylated extracellular matrix for digital light processing bioprinting: a practical workflow.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Decellularized extracellular matrix (dECM) materials are widely reported to present tissue-specific biochemical cues that influence cell behavior; here, we use porcine uterine dECM as a representative soft-tissue model to operationalize a practical digital light printing workflow. Digital light processing (DLP) offers high-fidelity, photopolymer-based fabrication that avoids shear stresses associated with extrusion and enables precise layer definition, yet its application to soft-tissue dECM remains limited. We produce and evaluate a standalone methacrylated dECM (dECM-MA) formulation and a stepwise, reproducible recipe using lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) and tartrazine. Histological and biochemical analyses confirm successful decellularization, substantial collagen retention, partial sGAG retention, and controlled methacrylation of accessible primary amine groups. The formulation prints via DLP to yield reproducibly defined acellular constructs at a 50-µm layer height and millimeter-scale geometries, demonstrating high dimensional fidelity and controlled swelling behavior. High resolution scanning electron microscopy (HR-SEM) imaging of printed ECM-MA and solid decellularized uterine tissue demonstrated no significant differences in porosity, pore size distribution profiles, and connectivity, as quantified by image analysis, suggesting similar capacity to support diffusion and cell penetration.
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