Evidence map›Paper›PMID 42057983›Full record

ArticleJournal of biomedical physics & engineering2026

The Role of Adipose Tissue-Derived Stem Cells together with Vitamin C on Survival of Rats with Acute Radiation Syndrome.

Seyed Mohammad Javad Mortazavi, Fatemeh Kadivar, Shahrokh Zare, Abolfazl Kanani, Mohammad Amin Mosleh-Shirazi, Sadegh Masoudi, Feridoun Karimi-Busheri, Davood Mehrabani

Abstract read
In one paragraph

Article in Journal of biomedical physics & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seyed Mohammad Javad MortazaviIonizing and Non-Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Fatemeh KadivarIonizing and Non-Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shahrokh ZareStem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abolfazl KananiIonizing and Non-Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Amin Mosleh-ShiraziIonizing and Non-Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sadegh MasoudiIonizing and Non-Ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Feridoun Karimi-BusheriDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Davood MehrabaniStem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Following any injury in radiation accidents, such as Acute Radiation Syndrome (ARS), medical interventions are recommended based on radiation dose and physiological response. Clinical management encompasses blood transfusion, hematopoietic cytokines, and stem-cell transplantation. Objective: This study aimed to determine the effect of adipose tissue-derived stem cells (AdSCs) together with vitamin C on the survival of rats with ARS. Material and Methods: In this experimental study, 45 rats were randomly divided into 3 equal groups of animals administered with a single dose of oral 400 mg/kg vitamin C; those injected intravenously with 1.5×10 Results: A significant increase in survival rate was visible one month after γ irradiation in 73.3% of animals received AdSCs+vitamin C, 60% of rats injected with just AdSCs, and 13.3% of the group received just vitamin C. Conclusion: Our findings revealed significant efficacy of a combined approach involving AdSC transplantation and vitamin C to enhance the survival rate following lethal irradiation. This combination could offer a potential avenue for addressing the alleviation of tissue damage caused by chemotherapy and toxic drugs. We recommend the administration of AdSCs together with vitamin C as an effective and prompt treatment option for irradiation injuries.

Indexed as

Acute Radiation SyndromeAdipose TissueMesenchymal Stem CellsRatSurvival

Identifiers

PMID42057983
PMCPMC13122367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.