ArticleJournal of biomedical physics & engineering2026
Investigating Depression and MRI Associations in Middle Eastern Relapsing-Remitting Multiple Sclerosis.
Article in Journal of biomedical physics & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: Multiple Sclerosis (MS) is often complicated by depression, worsening disability and quality of life. Global depression prevalence in MS is ~27%, but Middle Eastern data are scarce. The neurobiological basis of depression in Relapsing-Remitting Multiple Sclerosis (RRMS) is unclear. Objective: This study aimed to assess depression prevalence in Middle Eastern RRMS patients versus controls, evaluate disability using the Expanded Disability Status Scale (EDSS), and explore Magnetic Resonance Imaging (MRI) correlations with depressive symptoms. Material and Methods: In a cross-sectional study (June 2022-June 2023), 105 RRMS patients (mean age 36.2±13.9 years, 83.8% female) and 111 controls (mean age 39.1±10.9 years, 74.8% female) were recruited from Shiraz, Iran MS clinics. Depression was measured using the Beck Depression Inventory (BDI), disability via EDSS, and MRI (1.5-Tesla) analyzed for lesion burden and brain volume using VolBrain. Statistical analyses included t-tests, chi-squared tests, and correlations ( Results: Depression was more prevalent in RRMS patients (33.3%) than controls (24.5%; Conclusion: Depression affects one-third of Middle Eastern RRMS patients, exceeding controls. Limbic and insular plaque burdens suggest network dysconnectivity drives depressive symptoms. Routine screening and region-specific interventions are needed.
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