ReviewBiomaterial investigations in dentistry2026
Antibiotic approaches to endodontic regeneration.
Review in Biomaterial investigations in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comparative antioxidant efficacy of D-Cateslytin combined with modified triple antibiotic paste and calcium hydroxide: anFrontiers in dental medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regenerative endodontics (REs) has redefined the management of immature permanent teeth with necrotic pulps by shifting the objective from simple disinfection to biologically driven root maturation and restoration of the dentine-pulp complex. A critical component of this process is the selection of intracanal medicaments that can effectively eliminate microbial infection while preserving the viability of stem cells required for regeneration. This narrative review evaluates the biological and antimicrobial performance of commonly used medicaments, particularly calcium hydroxide (Ca(OH)₂) and triple antibiotic paste (TAP), and discusses their role in RE procedures. A literature search was conducted using PubMed/MEDLINE, Scopus, and Web of Science for articles published between January 2000 and March 2025. Although Ca(OH)₂ remains widely used due to its antimicrobial properties and ability to promote hard tissue formation, concerns remain regarding its high alkalinity and potential adverse effects on stem cell survival. TAP, in contrast, appears to provide a more supportive environment for dental pulp stem cell proliferation and attachment but is associated with drawbacks such as tooth discoloration and antibiotic-related limitations. Emerging alternatives, including double antibiotic paste (DAP) and nano-modified calcium hydroxide formulations, aim to improve the balance between antimicrobial efficacy and biocompatibility. Overall, current evidence emphasizes the importance of optimizing medicament concentration and duration of application to enhance the predictability and long-term success of RE therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.