ArticleHealth science reports2026
Association of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios With Three-Vessel Coronary Artery Disease: A Case-Control Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios With Three-Vessel Coronary Artery Disease: A Case-Control Study.Health science reports · 2026Article
- Reciprocal mediation of immuno-inflammation and insulin resistance in the risk of chronic kidney disease among patients with coronary artery disease: insights from neutrophil-to-lymphocyte ratio and triglyceride-glucose index.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Coronary artery disease (CAD) is a leading cause of mortality worldwide, with inflammation playing a crucial role in its pathogenesis. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are emerging as potential inflammatory biomarkers for CAD severity. This study investigates the association of NLR and PLR with three-vessel disease in patients undergoing elective coronary angiography. Methods: A registry-based case-control study was conducted on 300 patients at Imam Hossein Hospital, Tehran, Iran. Patients were randomly divided into two groups of 150: (1) CAD patients with three-vessel disease (≥ 50% stenosis) and (2) individuals with normal coronary angiograms. Demographic, clinical, and preoperative laboratory variables were compared between groups. Univariate and multivariable logistic regression analyses were performed to determine the predictive value of NLR and PLR. The models' performance was assessed using discrimination and calibration indices. Results: Patients with three-vessel CAD had a significantly higher prevalence of NLR ( ≥ 2.5) and PLR ( ≥ 130) than those with normal coronary arteries ( Conclusion: NLR is a significant predictor of severe CAD and may serve as a cost-effective inflammatory biomarker for risk stratification. PLR, while associated with CAD severity, may warrant further investigation. Future studies should explore additional inflammatory markers to enhance CAD risk assessment.
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