ArticleFrontiers in microbiology2026
Polymethyl methacrylate microplastics affect oral microbiota diversity and
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Introduction: Polymethyl methacrylate (PMMA)-a widely applied dental resin-based material-contributes to oral PMMA microplastics (PMMA-MPs) exposure through masticating. PMMA-MPs may facilitate pathogen adhesion, posing substantial risks to oral health. Dental caries represents the most prevalent chronic infectious oral disease, characterized by progressive lesions that may induce pain, tooth structure loss, and compromised masticatory efficiency. Methods: The impacts of PMMA-MPs were assessed using a standardized murine oral exposure model, followed by the quantification of PMMA-MPs-associated shifts in oral microbiota using high-throughput 16S rRNA gene sequencing. Compared with the control group, PMMA-MPs significantly altered the diversity of oral microbial communities in mice, with a notable increase in the relative abundance of Results: PMMA-MPs markedly enhanced the growth, biofilm formation, and virulence factor synthesis of Discussion: Overall, our results revealed that PMMA-MPs can alter the composition of the oral microbial community, while enhancing both the virulence factors and antibiotic tolerance of
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