In one paragraphArticle in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Ennian LiDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.ORCID 0000-0002-6761-7713 Balaji S KaleDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.ORCID 0000-0002-5049-5895 Abeje A SilteDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.ORCID 0000-0002-7312-0818 Rui LyuDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.
Neha UpadhyayDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.
Logan T NeelDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.ORCID 0000-0002-4685-2300 Ahmed RedaDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.
Huiqun WangDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.
William L DeweyDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, 410 North 12th Street, Richmond, Virginia 23298, United States.
Piyusha P PagareDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.ORCID 0000-0002-4848-2673 Yan ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States.ORCID 0000-0001-8934-7016 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The μ-opioid receptor (MOR) plays a key role in opioid addiction and fentanyl-induced respiratory depression. Phenylfentanyl, previously reported as a MOR antagonist, paradoxically induces respiratory depression in vivo, revealing a dissociation between receptor antagonism and respiratory liability within this scaffold. To interrogate structural determinants underlying this activity profile, phenylfentanyl was redesigned through systematic modification of the acyl chain,
Indexed as
Analgesics, OpioidFentanylNarcotic AntagonistsReceptors, Opioid, muRespiratory InsufficiencyAnimalsDose-Response Relationship, DrugHumansStructure-Activity RelationshipAnalgesics, OpioidFentanylNarcotic AntagonistsReceptors, Opioid, mucore ring extensionfentanylisosteric modificationphenylfentanylrespiratory depression
Identifiers
PMID42057745
PMCPMC13195661
What OpenQuestion holds
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LicenceCC BY
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