Evidence map›Paper›PMID 42057702›Full record

ArticleClinical pharmacology in drug development2026

A Phase 1, Open-Label, Single-Dose Study of the Effect of Hepatic Impairment on the Pharmacokinetics of Erdafitinib, an FGFR Inhibitor.

Wei Zhu, Peter Hellemans, Anna Mitselos, Marc De Meulder, Juhui James Jiao, Hui Tian

Abstract readClinical Trial, Phase I
In one paragraph

Article in Clinical pharmacology in drug development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei ZhuClinical Pharmacology & Pharmacometrics, Johnson & Johnson, Raritan, NJ, USA.
Peter HellemansOncology Research & Development, Johnson & Johnson, Beerse, Belgium.
Anna MitselosOncology Research & Development, Johnson & Johnson, Beerse, Belgium.
Marc De MeulderBioanalytical Discovery & Development Sciences, Johnson & Johnson, Beerse, Belgium.
Juhui James JiaoStatistics and Decision Science, Johnson & Johnson, Raritan, NJ, USA.
Hui TianClinical Pharmacology & Pharmacometrics, Johnson & Johnson, Spring House, PA, USA.

Funding

Johnson & Johnson, LLC
6 · The paper itself

Abstract

Erdafitinib, an oral pan-FGFR inhibitor is extensively metabolized in the liver. This open-label, single-dose, phase 1 study evaluated the pharmacokinetics (PK) of erdafitinib in participants with hepatic impairment versus healthy controls. Overall, 26 participants were enrolled. Following a single 6 mg oral dose, the maximum plasma concentration (C

Indexed as

Liver DiseasesProtein Kinase InhibitorsPyrazolesQuinoxalinesReceptors, Fibroblast Growth FactorAdministration, OralAdultAgedArea Under CurveFemaleHumansMaleMiddle AgedSeverity of Illness IndexYoung AdulterdafitinibProtein Kinase InhibitorsPyrazolesQuinoxalinesReceptors, Fibroblast Growth FactorerdafitinibFGFR‐tyrosine kinase inhibitorhepatic impairmentpharmacokinetic

Identifiers

PMID42057702
PMCPMC13129628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.