ArticleNeuropsychopharmacology reports2026
Context-Dependent Temporal Changes in Hypnotics Involved in Suicide Attempts.
Article in Neuropsychopharmacology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent prescribing practices have shifted from benzodiazepines (BZs) toward non-GABAergic hypnotics, including dual orexin receptor antagonists (DORAs) and melatonin receptor agonists (MRAs). We examined whether hypnotics involved in suicide attempts changed over time in a context-dependent manner.
methodsWe conducted a multicenter retrospective cohort study of consecutive patients presenting with suicide attempts at three hospitals in Japan between April 2020 and March 2025. Hypnotics involved in attempts were identified from empty medication packages collected at presentation. Annual proportions of BZs and non-GABAergic hypnotics (OMs: DORAs and MRAs) were analyzed using Cochran-Armitage trend tests under three conditions: (1) all suicide attempts, (2) overdose-related attempts, and (3) overdose-related attempts involving a hypnotic. Additional analyses separated DORAs from MRAs.
resultsAmong 1111 suicide attempt encounters, 648 were overdose-related. OM involvement increased significantly over time across all denominators. In contrast, BZ involvement declined significantly only among overdose-related attempts. When OMs were disaggregated, DORA involvement showed a significant upward trend using overdose-related attempts as the denominator (χ
conclusionHypnotics involved in suicide attempts changed in a context-dependent manner during the study period. The increase in non-GABAergic hypnotics was driven by DORAs, whereas reductions in BZ involvement were detectable only in overdose-related contexts. These findings suggest that evolving hypnotic availability may influence the profile of medications involved in self-poisoning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.