Evidence map›Paper›PMID 42057595›Full record

ArticleThe British journal of psychiatry : the journal of mental science2026

From early intervention in psychosis to intensive care: correlates of restrictive psychiatric practice in a national retrospective cohort study.

Ryan Williams, Edward Penington, Veenu Gupta, Michelle Rickett, Joel Agorinya, Apostolos Tsiachristas, Carolyn A Chew-Graham, Jonathan Woodward, David Shiers, Alex Bottle and 4 more

Abstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ryan WilliamsDivision of Psychiatry, https://ror.org/041kmwe10Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-8486-4903
Edward PeningtonDepartment of Psychiatry, University of Oxford, Oxford, UK.
Veenu GuptaDepartment of Psychology, Durham University, Durham, UK.
Michelle RickettResearch Institute for Primary Care and Health Sciences, Keele University, Newcastle, UK.
Joel AgorinyaDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-3963-1710
Apostolos TsiachristasDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-4662-8915
Carolyn A Chew-GrahamResearch Institute for Primary Care and Health Sciences, Keele University, Newcastle, UK.
Jonathan WoodwardSchool of Medicine and Population Health, University of Sheffield, Sheffield, UK.
David ShiersResearch Institute for Primary Care and Health Sciences, Keele University, Newcastle, UK.
Alex BottleDivision of Psychiatry, https://ror.org/041kmwe10Imperial College London, London, UK.
Benjamin McNeillishttps://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.
Paul FrenchDepartment of Research and Innovation, Pennine Care NHS Foundation Trust, Ashton-under-Lyne, UK.
Belinda R LennoxDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-4972-8786
Mike J CrawfordDivision of Psychiatry, https://ror.org/041kmwe10Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-3137-5772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRestrictive interventions are used in the treatment of some people with severe mental disorders such as psychosis - including psychiatric intensive care unit (PICU) admission, seclusion and restraint. Early Intervention in Psychosis (EIP) service input may improve outcomes in psychosis, but it is unclear whether specific components of EIP care reduce the need for restrictive practice.

aimsTo examine associations between EIP care components, demographic characteristics and restrictive interventions.

methodWe conducted a retrospective cohort study of 14 874 people who used EIP services in England, using linked data from the National Clinical Audit of Psychosis and the Mental Health Services Data Set. We examined associations between EIP components and time to PICU admission (primary outcome) alongside seclusion/physical restraint/injected chemical restraint/requests for police assistance (secondary outcomes), using multilevel Cox regression, adjusting for demographic factors and clustering by service.

resultsHigher hazards of restrictive interventions were observed among men, younger people and several minority ethnic groups. Individuals eligible for clozapine who were not offered it (hazard ratio 1.51, 95% CI 1.20-1.91) or refused it (hazard ratio 1.46, 95% CI 1.02-2.10) had higher hazards of PICU admission than those not eligible, whereas those who were eligible for clozapine and received it did not. There was weaker evidence of similar effects on hazards of physical restraint and seclusion. Receipt of CBT for psychosis was associated with reduced hazards of PICU admission (hazard ratio 0.80, 95% CI 0.67-0.95) and physical restraint (hazard ratio 0.68, 95% CI 0.47-0.98). Substance use was associated with increased hazards of PICU admission and requests for police assistance, although substance use interventions appeared to partially mitigate this.

conclusionsMarked demographic disparities exist in the use of restrictive practice. Specific EIP care components may be associated with reductions. Strengthening evidence-based EIP provision and addressing structural inequalities may support progress towards less coercive and more equitable care.

Indexed as

CBTpclozapineEarly interventionpsychosisrestrictive practice

Identifiers

PMID42057595
PMCPMC7619183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.