ArticleTransfusion2026
Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness.
Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
12 authors.
Funding
Abstract
backgroundPlatelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non-immune mechanisms. Although alloantibodies are well-established contributors, Fc-independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance. STUDY DESIGN AND
methodsIn this prospective diagnostic study, 81 patients with suspected PTR were evaluated using an integrated approach combining the platelet immunofluorescence test (PIFT) to detect antibody-mediated refractoriness and a modified platelet desialylation test (PDT) to assess Fc-independent clearance. Demographic, clinical, and laboratory variables were analyzed using non-parametric tests, including Mann-Whitney U, Kruskal-Wallis, and binomial tests.
resultsThe cohort exhibited severe thrombocytopenia and diverse clinical profiles. PIFT detected platelet-bound antibodies in 63/81 cases (78%), while PDT identified desialylation in 41/81 patients (50%). PIFT positivity was similar between PDT-positive (80.5%) and PDT-negative (76.9%) groups, with no significant association (χ DISCUSSION: PTR occurs both independently and in parallel with antibody-mediated pathways. The combined PIFT-modified PDT approach improves mechanistic characterization and enhances diagnostic accuracy, in cases of platelet refractoriness of immune and non-immune etiology.
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