Evidence map›Paper›PMID 42057468›Full record

Trial reportJournal of biophotonics2026

Combined Low-Level Laser and Ultrasound Therapy for Growing Pains in Children Aged Four to Twelve Years: A Pilot Study.

Esther Angelica Luiz Ferreira, Lucas Pereira Liberal, Antonio Eduardo de Aquino Junior, Rodrigo Bezerra de Menezes Reiff, Fernanda Mansano Carbinatto, Ricardo Patrezi Zanatta, Matheus Henrique Camargo Antonio, Noahn Gabriel Silva Pereira, Maycon Rodrigo Sarracini, Vanderlei Salvador Bagnato

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of biophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Esther Angelica Luiz FerreiraFederal University of São Carlos, São Carlos, São Paulo, Brazil.ORCID 0000-0003-2582-9045
Lucas Pereira LiberalFederal University of São Carlos, São Carlos, São Paulo, Brazil.ORCID 0009-0004-8414-8236
Antonio Eduardo de Aquino JuniorInstitute of Physics of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil.
Rodrigo Bezerra de Menezes ReiffFederal University of São Carlos, São Carlos, São Paulo, Brazil.
Fernanda Mansano CarbinattoInstitute of Physics of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil.ORCID 0009-0008-0374-2081
Ricardo Patrezi ZanattaFederal University of São Carlos, São Carlos, São Paulo, Brazil.
Matheus Henrique Camargo AntonioInstitute of Physics of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil.
Noahn Gabriel Silva PereiraFederal University of São Carlos, São Carlos, São Paulo, Brazil.
Maycon Rodrigo SarraciniFederal University of São Carlos, São Carlos, São Paulo, Brazil.
Vanderlei Salvador BagnatoInstitute of Physics of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil.ORCID 0000-0003-4833-239X

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico
6 · The paper itself

Abstract

Growing pains are a frequent form of musculoskeletal pain in children, with an uncertain etiology and currently limited therapeutic options. Considering the need for non-pharmacological approaches, the potential of low-level laser therapy combined with ultrasonic therapy stands out as a possible therapeutic technique for this condition. The objective of this study was to analyze the safety and efficacy of this treatment in children diagnosed with growing pains in order to justify the development of further research on the same topic. After confirmation of the diagnosis, participants were randomized into a treatment group, treated with the laser and ultrasound-emitting equipment, and a placebo group. Pain was assessed at three time points and recorded in a diary for 30 days. The results indicated clinical safety and possible efficacy, reinforcing the need for further clinical trials on the subject.

Indexed as

Low-Level Light TherapyPain ManagementUltrasonic TherapyChildChild, PreschoolCombined Modality TherapyFemaleHumansMalePilot Projectschildlaser therapymusculoskeletal painultrasonic therapy

Identifiers

PMID42057468
PMCPMC13129411

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.