Evidence map›Paper›PMID 42057175›Full record

ArticleHead & face medicine2026

Effects of extended guided bone regeneration on the labial alveolar wall of adjacent teeth in the anterior maxilla: a retrospective cohort study.

Xingchao Zeng, Hao Chen, Yifan Jiang, Yuting Wen, Jiaxin Luo, Fuchun Chen, Bin Chen, Shiyong Zhao, Tong Xi

Abstract read
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In one paragraph

Article in Head & face medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xingchao Zeng *Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Hao Chen *Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Yifan Jiang *Department of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Yuting WenDepartment of Stomatology, Zigong Fourth People's Hospital, Zigong, China.
Jiaxin LuoDepartment of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Fuchun ChenDepartment of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Bin ChenDepartment of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China. peterchenbin@126.com.
Shiyong ZhaoDepartment of Oral Implantology, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, and Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China. syzhao@gzhmu.edu.cn.
Tong XiDepartment of Oral and Maxillofacial Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, PO Box 9101, Nijmegen, 6500HB, the Netherlands.

Funding

Medical Scientific Research Foundation of Guangdong Province B2023387
6 · The paper itself

Abstract

backgroundThe thin labial alveolar wall (LAW) of anterior maxillary teeth is prone to resorption after flap surgery, jeopardizing aesthetic outcomes. This study evaluated whether extended guided bone regeneration (GBR) to cover the LAW of adjacent teeth mitigates this bone loss.

methodsIn this retrospective cohort study, we categorized adjacent teeth into three groups according to the intraoperative extension of the graft relative to the LAW: Non-Extended GBR (NE-GBR; graft confined to edentulous site), Partially Extended GBR (PE-GBR; graft on partial BBW), and Fully Extended GBR (FE-GBR; graft covering BBW to the crest). Horizontal LAW thickness and vertical distance from cementoenamel junction to the alveolar crest were measured on superimposed pre-operative and 6-month post-operative CBCT scans.

resultsAnalysis included 135 adjacent teeth (80 patients). Significant horizontal resorption occurred in the NE-GBR (- 0.40 ± 0.32 mm) and PE-GBR (- 0.43 ± 0.44 mm) groups (p < 0.001), while the FE-GBR group maintained stable dimensions (0.15 ± 0.75 mm, p = 0.523). Vertically, the FE-GBR group showed a significant dimensional gain (0.43 ± 1.10 mm, p < 0.001), unlike the resorption seen in other groups. Mixed-effects models confirmed FE-GBR as a significant positive predictor for both horizontal (β = 0.48, p < 0.001) and vertical (β = 0.48, p = 0.001) dimensional preservation.

conclusionsFully extended GBR to cover the LAW up to the crest appears to counteract post-surgical reduction, better preserving radiographic alveolar ridge dimensions in the aesthetic zone over a 6-month period.

trial registrationThis study protocol was approved by the Institutional Review Board (LCYJ20250303005) and was registered in the Chinese Clinical Trial Registry (ChiCTR2500099603).

Indexed as

Alveolar Bone LossAlveolar ProcessBone RegenerationGuided Tissue Regeneration, PeriodontalMaxillaAdultCohort StudiesCone-Beam Computed TomographyFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeAdjacent teethAesthetic zoneAnterior maxillaBone resorptionDental implantsGuided bone regenerationLabial alveolar wall

Identifiers

PMID42057175
PMCPMC13277318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.