ArticleOrphanet journal of rare diseases2026
Prevalence of depressive and anxiety symptoms among patients consulting a rare disease outpatient clinic for rare and undiagnosed diseases in China.
Article in Orphanet journal of rare diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPatients with rare diseases often experience significant psychological distress. This study aims to assess the prevalence of depressive and anxiety symptoms and identify associated factors among patients consulting a rare disease outpatient clinic for rare and undiagnosed diseases in China.
methodsA clinic-based cross-sectional study was conducted from February to June 2024, with 201 participants recruited. Sociodemographic, health-related characteristics, and psychological symptoms were assessed using validated instruments. Multivariable logistic regression was performed to identify factors associated with depressive and anxiety symptoms.
resultsOverall, 68.2% of participants reported depressive symptoms, and 41.3% reported anxiety symptoms. Poor sleep quality (OR = 10.298, 95%CI: 1.915–55.367) and pain or discomfort (OR = 2.292, 95% CI: 1.143–4.596) were associated with a higher likelihood of depressive symptoms. For anxiety symptoms, confrontation (OR = 1.143, 95% CI: 1.042–1.253) and acceptance-resignation (aOR = 1.166, 95% CI: 1.051–1.294) were positively associated with anxiety symptoms. Higher social support was a protective factor of both depressive symptoms (aOR = 0.893, 95%CI: 0.813–0.98) and anxiety symptoms (aOR = 0.885, 95%CI: 0.817–0.959).
conclusionsThese findings highlight the substantial psychological burden faced by patients consulting a rare disease outpatient clinic in China and underscore the importance of integrating mental health support into the multidisciplinary care. Routine psychological screening and timely support can improve patients’ overall well-being and quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.