Evidence map›Paper›PMID 42057117›Full record

ArticleRespiratory research2026

Krüppel-like factor 14 enhances fatty acid oxidation to combat pulmonary fibrosis.

Jingrui Ren, Ruijie Wan, Shuai Zhou, Xinran Ma, Chenxi Zhu, Jinxin Ma, Jianqiao Chen, Limin Zhao, Wenjuan Wu

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In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jingrui Ren *Department of Geriatrics, People's Hospital of Zhengzhou University, No. 100 Science Avenue, High-Tech Zone, Zhengzhou, Henan Province, China.
Ruijie Wan *Department of Geriatrics, Henan Provincial People's Hospital, Zhengzhou University, No. 7, Weiwu Road, Jinshui District, Zhengzhou, Henan Province, China.
Shuai ZhouCenter for Translational Medicine, Zhengzhou University, Zhengzhou, China.
Xinran MaDepartment of Geriatrics, People's Hospital of Zhengzhou University, No. 100 Science Avenue, High-Tech Zone, Zhengzhou, Henan Province, China.
Chenxi ZhuDepartment of Geriatrics, People's Hospital of Henan University, No. 85 Minglun Street, Shunhe Hui District, Kaifeng, Henan Province, China.
Jinxin MaDepartment of Respiratory and Critical Care Medicine, Clinical Medical College of Zhengzhou University, Zhengzhou, China.
Jianqiao ChenDepartment of Geriatrics, Henan Provincial People's Hospital, Zhengzhou University, No. 7, Weiwu Road, Jinshui District, Zhengzhou, Henan Province, China.
Limin ZhaoDepartment of Respiratory and Critical Care Medicine, Clinical Medical College of Zhengzhou University, Zhengzhou, China.
Wenjuan WuDepartment of Geriatrics, People's Hospital of Zhengzhou University, No. 100 Science Avenue, High-Tech Zone, Zhengzhou, Henan Province, China. wuwj2016@zzu.edu.cn.

Funding

Key Project of Henan Province Medical Science and Technology Research Plan No. SBGJ202402013
6 · The paper itself

Abstract

backgroundIdiopathic pulmonary fibrosis (IPF) is a progressive lung disorder with few effective treatments. This study examines how Krüppel-like factor 14 (KLF14) influences fatty acid oxidation (FAO) and fibroblast senescence in IPF.

methodsA rat model of IPF was induced using bleomycin. Expression levels of KLF14, CPT1A, and related proteins were measured using qRT-PCR and Western blot. Lung tissue histology was examined, and cellular senescence was evaluated using SA-β-gal staining. The transcriptional regulation of CPT1A by KLF14 was confirmed through luciferase reporter assays and ChIP.

resultsKLF14 expression was significantly downregulated in the IPF model. Overexpression of KLF14 reduced collagen deposition, attenuated fibroblast senescence, and enhanced FAO by upregulating CPT1A. Mechanistically, KLF14 binds to the CPT1A promoter, promoting its transcription.

conclusionsKLF14 enhances FAO through CPT1A activation, offering a novel therapeutic strategy for IPF.

Indexed as

Fatty AcidsIdiopathic Pulmonary FibrosisKruppel-Like Transcription FactorsAnimalsBleomycinCarnitine O-PalmitoyltransferaseFibroblastsHumansMaleOxidation-ReductionRatsRats, Sprague-DawleyBleomycinCarnitine O-PalmitoyltransferaseFatty AcidsKruppel-Like Transcription FactorsBleomycinCarnitine Palmitoyltransferase 1ACellular SenescenceFatty Acid OxidationIdiopathic Pulmonary FibrosisKrüppel-like Factor 14

Identifiers

PMID42057117
PMCPMC13289472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.