Evidence map›Paper›PMID 42057082›Full record

ArticleTrials2026

Efficacy of transcutaneous spinal cord stimulation combined with resistance training on motor function in motor-incomplete spinal cord injury: protocol for an open-label, single-blind randomized controlled trial.

Jibao Chen, Xiaoming Luo, Yuxin Zhang, Yingguo Li, Yan Wang, Jiamei Ye, Jing Sun, Handong Huang, Zengqiang OuYang, Yaxin Yuan and 1 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jibao ChenDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.ORCID http://orcid.org/0000-0002-8702-3584
Xiaoming LuoDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Yuxin ZhangDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Yingguo LiDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Yan WangDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Jiamei YeDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Jing SunDepartment of Radiology, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Handong HuangDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Zengqiang OuYangDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Yaxin YuanDepartment of Physiotherapy, Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China.
Yue WangDepartment of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 201619, China. wangyuesh@126.com.ORCID http://orcid.org/0000-0003-0287-9015

Funding

National Key Clinical Specialty Discipline Construction Program of China Z155080000004Shanghai Shenkang Hospital Development Center SHDC2025CCS042Songjiang District Science and Technology Project 2024SJKJGG051Songjiang District Science and Technology Project 2024SJKJGG115
6 · The paper itself

Abstract

backgroundSpinal cord injury (SCI) commonly results in substantial motor impairments, particularly in standing and walking abilities, due to the disruption of the sensory-motor circuits. Conventional rehabilitation approaches have limited effectiveness in restoring motor function. The present study investigates the combined effects of transcutaneous spinal cord stimulation (tSCS) and resistance training (RT) on improving motor function in patients with motor-incomplete SCI. Furthermore, it examines the underlying mechanisms of these improvements through the use of advanced neuroimaging and electrophysiological techniques.

methodsThis open-label, single-blind, randomized controlled trial will be conducted over 28 days at Shanghai Yangzhi Rehabilitation Hospital. A total of 56 participants with motor-incomplete SCI will be randomly assigned to two groups: the intervention group (tSCS + RT) and the control group (RT only). The intervention group will receive tSCS in combination with RT 3 times per week for 4 weeks, while the control group will undergo RT without tSCS. Primary outcomes will include peak torque measurements and secondary outcomes will involve motor functions and multimodal neurofunctional metrics. Data will be analyzed to evaluate the efficacy of the combined treatment in improving lower limb motor function. DISCUSSION: The novel combination of tSCS and RT aims to enhance motor function by providing dual-channel neuromodulation that targets both sensory and motor pathways. The results of this study could inform future therapeutic strategies and the broader clinical application of neuromodulation technologies in spinal cord injury rehabilitation.

trial registrationThis study was prospectively registered at the Chinese Clinical Trials Registry, ChiCTR2400089603, registered on September 11, 2024, https://www.chictr.org.cn .

Indexed as

Motor ActivityResistance TrainingSpinal Cord InjuriesSpinal Cord StimulationAdolescentAdultAgedChinaCombined Modality TherapyFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicRecovery of FunctionSingle-Blind MethodMotor functionResistance trainingSpinal cord injuryStrengthTranscutaneous spinal cord stimulation

Identifiers

PMID42057082
PMCPMC13267515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.