ArticleBMC pediatrics2026
Establishing a nomogram of the risk of in-hospital mortality in children with suspected sepsis and validating the applicability of the Phoenix.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to develop a nomogram for assessing the risk of in-hospital mortality in children with suspected sepsis admitted to pediatric intensive care unit (PICU). Additionally, it sought to evaluate the applicability of the most recent international diagnostic criteria for pediatric sepsis, the Phoenix diagnostic criteria.
methodsData were collected from electronic medical records of pediatric sepsis patients admitted to the PICU at West China Second Hospital, Sichuan University, between January 1, 2021, and August 31, 2023, within the first 24 h of admission. A total of 539 children were randomly assigned to two groups: a training set (n = 458, 85%) and a validation set (n = 80, 15%). The LASSO regression was employed for variable selection. Multivariable logistic regression analysis was used to construct a predictive model incorporating the predictors selected through LASSO regression. A nomogram was constructed based on the selected variables for visual representation. Model validation was performed using a calibration plot, ROC curve, and DCA. The AUC of this model were compared with those of the SIRS, PELODS-2, pSOFA, PMODS, and Phoenix criteria. Subsequently, the pSOFA, SIRS, and Phoenix criteria were applied to data collected within the first 24 h of PICU admission to compare mortality rates based on these criteria in patients with suspected sepsis.
resultsAmong the 42 variables examined, LASSO regression analysis identified six significant predictors: urea, P/F ratio, mechanical ventilation, HCO
conclusion(1) The inclusion of P/F ratio, mechanical ventilation, HCO
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