ArticleBMC medical imaging2026
CT-based radiomics to predict peri-device leakage after left atrial appendage closure.
Article in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPeri-device leakage (PDL) is one of the major complications of left atrial appendage closure (LAAC). However, there is a lack of predictive models in clinical practice. The aim of this study was to develop and validate a prediction model for PDLs after LAAC based on preoperative CT and CT-based radiomic features.
methodsThis retrospective cohort study included 100 patients with nonvalvular atrial fibrillation who underwent LAAC between August 2023 and August 2024 at two centers. A clinical model was constructed via binary logistic regression with clinical information, and a radiomic model was constructed via conventional CT measurements and radiomic features. A combined model was also constructed by combining clinical information and imaging features. The performance of all the models was evaluated and compared, and internal validation was performed via the bootstrap method.
resultsMultivariate analysis revealed that the least axis length, larger diameter, and hypertension grade 3 were independent risk factors for PDLs. The combined model constructed based on these three factors (AUC: 0.796, 95% CI: 0.704–0.888) was superior to the clinical model (AUC: 0.711, 95% CI: 0.605–0.817) and the radiomic model (AUC: 0.743, 95% CI: 0.641–0.845).
conclusionsThis study is the first to find that the least axis length of the LAA was an independent risk factor for the PDL. The combined model demonstrated a high degree of reliability in predicting the PDL at 3 months following LAAC. This model exhibited a greater predictive capacity than the clinical model and radiomic model did.
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