Trial reportBMC primary care2026
Transdiagnostic cognitive behavioral therapy for severe and persistent fatigue - a feasibility study in primary care.
Trial report in BMC primary care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06341751 (Psychological Treatment for Persistent Fatigue), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychological Treatment for Persistent Fatigue: a Feasibility Study
Who cites it
1 citing paper in PubMed.
- Fatigue: assess and address it.Journal of patient-reported outcomes · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFatigue is the main complaint of 5–10% of patients in primary care and is often associated with significant suffering and functional disability. Cognitive behavioral therapy (CBT) has demonstrated efficacy in reducing fatigue severity in diverse clinical populations in specialized healthcare settings, with common treatment mechanisms identified across conditions. This study is the first to evaluate the feasibility and acceptability of a transdiagnostic CBT (tCBT) for a heterogeneous sample of patients suffering from severe and persistent fatigue in a primary care context.
methodsA single-arm feasibility study was conducted in routine primary care. Adults with severe and persistent fatigue received a blended tCBT combining individual sessions and internet-based materials. Feasibility and acceptability were evaluated through adherence, completion, attrition, therapist fidelity, patient satisfaction, credibility, and negative effects. Preliminary effectiveness was evaluated by self-reported symptom change from pre- to post-treatment (6 months).
resultsEighteen participants were enrolled, of whom fourteen completed the full intervention. Treatment adherence and therapist fidelity were satisfactory, and data attrition was minimal. Participants reported high satisfaction and treatment credibility. No serious adverse events were reported. Half of the participants reported some negative effects of treatment, primarily consisting of transient increases in fatigue and sleep disturbances. Large within-group reductions were observed in self-reported fatigue severity and functional impairment over the 6-month treatment period.
conclusionsPreliminary findings suggest that tCBT for fatigue is feasible and acceptable in a primary care setting. Interpretation is limited by the small sample size and single-arm design. Larger randomized controlled trials are warranted to evaluate effectiveness and to determine which patients benefit most and through which mechanisms.
trial registrationPre-registered on Clinicaltrials.gov (NCT06341751), registration date: 2024-03-13.
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