Evidence map›Paper›PMID 42056874›Full record

ArticleBMC cardiovascular disorders2026

Prognostic significance of circulating level of GRP78 in pulmonary arterial hypertension.

Jingyuan Chen, Wenjie Chen, Zilu Li, Jun Luo, Haihua Qiu, Yusi Chen, Jiang Li

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Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jingyuan Chen *Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China.
Wenjie Chen *Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China.
Zilu LiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China.
Jun LuoDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China.
Haihua QiuDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China.
Yusi ChenDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China.
Jiang LiDepartment of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Furong District, Changsha City, Hunan Province, 410011, China. lijiangcs@csu.edu.cn.ORCID http://orcid.org/0000-0003-4904-6635

Funding

Changsha Natural Science Foundation kq2202392General Funding Project of Hunan Provincial Health Commission 202103010961General Funding Project of Hunan Provincial Health Commission W20243239National Natural Science Foundation of China 82470055
6 · The paper itself

Abstract

backgroundEndoplasmic reticulum (ER) stress is associated with pulmonary arterial hypertension (PAH), and glucose-regulated protein 78 (GRP78) is an important marker of ER stress in PAH. Most studies have shown that its expression is increased at both lung and right ventricle as well as pulmonary vascular cells during ER stress. Currently, circulating GRP78 levels are also shown to be significantly increased in several diseases and can be used as a disease biomarker.

methodsCulture media from pulmonary artery smooth muscle cells (PASMCs) and cardiomyocytes with different trigger interventions were collected. Plasma was harvested from control, monocrotaline (MCT)-treated and Sugen-hypoxia (SuHx) treated rats. Plasma was also collected from 66 PAH patients and 40 healthy controls. GRP78 levels were measured by ELISA.

resultsThe extracellular GRP78 levels were significantly increased in hypoxia-treated PASMCs and cardiomyocytes compared with the normoxia group. Circulating levels of GRP78 were significantly increased in the MCT and SuHx groups compared with the control group. Circulating GRP78 levels are higher in PAH patients. In subgroup analyses, GRP78 was higher in the Idiopathic PAH (IPAH), Congenital heart disease-associated PAH (CHD-PAH), world heart World Health Organization Function Class (WHO-FC) III/IV, and intermediate-high-risk groups. Cox regression analysis (hazard ratio, HR) and Kaplan-Meier survival analysis showed that GRP78 was a prognostic risk factor for event-free survival (HR 1.422 per 1 µg/mL, 95% CI 1.188–1.702).

conclusionIn PAH, circulating GRP78 is significantly elevated and serves as an incremental prognostic biomarker for event-free survival.

Indexed as

Arterial PressureEndoplasmic Reticulum StressHeat-Shock ProteinsPulmonary Arterial HypertensionPulmonary ArteryAdultAnimalsBiomarkersCase-Control StudiesCells, CulturedDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPFamilial Primary Pulmonary HypertensionFemaleHumansMaleBiomarkersEndoplasmic Reticulum Chaperone BiPGRP78 protein, ratHeat-Shock ProteinsHSPA5 protein, humanEndoplasmic reticulumGlucose-regulated protein-78 (GRP78)PrognosisPulmonary arterial hypertension (PAH)

Identifiers

PMID42056874
PMCPMC13270839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.