A novel yeast extract from a multi-stress-resistant Saccharomyces cerevisiae confers potent antioxidant and UV-protective activities to skin cells.

Xueyu Yang, Xinyi Zhang, Minjia Yuan, Qi Li, Xinchen Teng

Abstract read

In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xueyu YangCollege of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.

Xinyi ZhangShanghai Qiran Biotechnology Co., Ltd., Shanghai, 201702, China.

Minjia YuanShanghai Qiran Biotechnology Co., Ltd., Shanghai, 201702, China.

Qi LiShanghai Qiran Biotechnology Co., Ltd., Shanghai, 201702, China.

Xinchen TengInternational College of Pharmaceutical Innovation, Soochow University, Suzhou, 215222, China. xcteng@suda.edu.cn.

Funding

National Natural Science Foundation of China 31970550

6 · The paper itself

Abstract

Yeast extract derived from Saccharomyces cerevisiae is a well-established cosmetic ingredient known for its diverse biological benefits, including UV protection. However, the directed optimization of yeast strains to obtain extracts with enhanced UVA protection for skin cells has not been previously reported. In this study, we developed a novel directed screening strategy to isolate a UVA-tolerant mutant strain, A154, which also exhibits multi-stress tolerance, including resistance to heat, oxidative stress, and UV radiation. Yeast extract from the A154 strain demonstrated significantly stronger UVA-protective and reactive oxygen species (ROS)-scavenging properties in human skin cell lines compared with the parental strain. In the presence of 0.5% A154 yeast extract, cell viability was increased by approximately 1.7-fold (HFF, 120 kJ/m

Indexed as

AntioxidantsRadiation-Protective AgentsSaccharomyces cerevisiaeSkinCell LineCell SurvivalHumansOxidative StressReactive Oxygen SpeciesUltraviolet RaysAntioxidantsRadiation-Protective AgentsReactive Oxygen SpeciesAntioxidantSaccharomyces cerevisiaeStrain mutagenesisUV protectionYeast extract

Identifiers

PMID42056863

DOI10.1186/s12866-026-05047-y

PMCPMC13237927

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.