Pharmacokinetic-pharmacodynamic integration of shikimic acid in broilers: An indirect effect modeling approach.

Yue Shen, Kaibin Mo, Hui Zhao, Yicheng Zhang, Xianhui Huang

Abstract read

In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yue ShenNational Veterinary Drug Residue Standard Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Microbial Resistance Risk Assessment Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Kaibin MoNational Veterinary Drug Residue Standard Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Microbial Resistance Risk Assessment Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Hui ZhaoNational Veterinary Drug Residue Standard Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Microbial Resistance Risk Assessment Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Yicheng ZhangNational Veterinary Drug Residue Standard Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Microbial Resistance Risk Assessment Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Xianhui HuangNational Veterinary Drug Residue Standard Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Drug Safety Evaluation (Environmental Assessment) Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; National Veterinary Microbial Resistance Risk Assessment Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. Electronic address: xhhuang@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shikimic acid (SA), a natural polyhydroxy cyclic organic acid, possesses significant anti-inflammatory and antioxidant activities; however, its pharmacokinetic (PK) profile and pharmacodynamic (PD) relationship in poultry remain poorly characterized. This study aimed to elucidate the PK characteristics of SA in broilers and its PD regulatory patterns on serum antioxidant indices. Sixteen healthy 5-week-old broilers were randomly assigned to intravenous (IV) and oral (PO) groups (50 mg/kg BW). Plasma SA concentrations were dynamically monitored via HPLC-MS/MS, while serum malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) were quantified simultaneously. PK parameters were calculated using non-compartmental analysis (NCA), and PK-PD integration was performed using an indirect effect model. The results showed that after IV administration, SA was extensively distributed and rapidly eliminated, with an apparent volume of distribution (V

Indexed as

AntioxidantsChickensShikimic AcidAdministration, OralAnimalsBiological AvailabilityHalf-LifeMaleModels, BiologicalRandom AllocationAntioxidantsShikimic AcidBioavailabilityBroilersIndirect effect modelPharmacokineticsShikimic acid

Identifiers

PMID42056829

DOI10.1016/j.psj.2026.106959

PMCPMC13141713

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.