ArticleVirulence2026
Conserved deletion of two consecutive glycine residues in the 100K protein is a critical determinant of FAdV-11 pathogenicity.
Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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16 authors.
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Abstract
Fowl adenovirus serotype 11 (FAdV-11) causes inclusion body hepatitis, posing a persistent threat to poultry health. However, the genetic determinants governing its pathogenicity remain unclear. Comparative analysis of pathogenic and nonpathogenic FAdV-11 strains revealed that nonpathogenic strains exhibit a conserved deletion of two consecutive glycine residues (Δ2G) in the glycine-rich domain of the 100K protein. This deletion is associated with a corresponding two-glutamic-acid deletion (Δ2E) in the glutamic acid-rich domain of the 33K protein. Here, we investigated the functional significance of two consecutive glycine residues in the virulence of FAdV-11 using the reverse genetics system of a pathogenic FAdV-11 strain. A recombinant mutant, rFAdV-11-100K-Δ2G, was generated with a seamless deletion of 2G in 100K. The
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