ArticleInternational journal of clinical oncology2026
Age-related prognostic trends in surgically resected female lymph node-metastatic gastric cancer: insights from SEER.
Article in International journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUnderstanding the relationship between age and prognosis of female lymph node-metastatic gastric cancer (FLMGC) remains limited. This study aimed to elucidate the prognostic impact of age on FLMGC.
methodsThis population-based retrospective analysis used data from the SEER database. After applying the exclusion criteria, a final cohort of 1,172 FLMGC cases was included. The patients were categorized by age into five groups: ≤ 50 years (n = 144), 51-60 years (n = 192), 61-70 years (n = 291), 71-80 years (n = 325), and ≥ 81 years (n = 220). Cancer-specific survival (CSS) was selected as the outcome in this study.
resultsSignificant factors for CSS identified in multivariate analysis included age, tumor differentiation, AJCC T and N stages, systemic therapy, number of positive lymph nodes, and total number of retrieved lymph nodes. Age had a nonlinear effect on CSS (P for nonlinearity < 0.001), with the lowest risk occurring in the 55-60 year age group.
conclusionsThis SEER-based study revealed a nonlinear relationship between age and FLMGC prognosis, with the lowest risk occurring in the 55-60-year age group.
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