Evidence map›Paper›PMID 42056534›Full record

ReviewPediatric research2026

Neonatal sepsis and cardiovascular dysfunction II: assessment.

Sophie M Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Michaela Pentony, Franz B Plötz, Tobias Strunk, Marina Degtyareva, Helmut Küster, Eric Giannoni, Joseph M Bliss and 9 more

Abstract readReview
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In one paragraph

Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sophie M DuignanDepartment of Paediatric Cardiology, Children's Health Ireland at Crumlin, Dublin, Ireland.
Satyan LakshminrusimhaDepartment of Pediatrics, UC Davis Children's Hospital, Sacramento, CA, USA.
Kathryn ArmstrongChildren's Heart Centre, BC Children's Hospital, Vancouver, BC, Canada.
Michaela PentonyDepartment of Paediatric Cardiology, Children's Health Ireland at Crumlin, Dublin, Ireland.
Franz B PlötzDepartment of Paediatrics, Tergooi Hospital, Hilversum, The Netherlands.
Tobias StrunkWesfarmers' Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia.
Marina DegtyarevaDepartment of Neonatology, Pirogov Russian National Research Medical University, Moscow, Russia.
Helmut KüsterNeonatology, Clinic for Paediatric Cardiology, Intensive Care and Neonatology, University Medical Centre Göttingen, Göttingen, Germany.
Eric GiannoniClinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Joseph M BlissDepartment of Pediatrics, Women & Infants Hospital of Rhode Island, Alpert Medical School of Brown University, Providence, RI, USA.
H Rob TaalDepartment of Neonatal and Paediatric Intensive Care, Division of Neonatology, ErasmusMC, University Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands.
Claus KlingenbergDepartment of Paediatrics, University Hospital of North Norway, Tromsø, Norway.
Lars NaverDepartment of Neonatology, Karolinska University Hospital and Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Jan JanotaDepartment of Obstetrics and Gynecology, Neonatal unit, Second Faculty of Medicine, Motol University Hospital and Charles University, Prague, Czechia.
Agnes van den HoogenWilhelmina Children's Hospital, Woman and Baby, Neonatology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.
Willem P de Boode *Department of Neonatology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, The Netherlands.
Orla Franklin *Department of Paediatric Cardiology, Children's Health Ireland at Crumlin, Dublin, Ireland.
Eleanor J Molloy *Discipline of Paediatrics, Trinity College, The University of Dublin, Trinity Research in Childhood (TRiCC) & Trinity Translational Medicine Institute (TTMI), Dublin, Ireland. eleanor.molloy@tcd.ie.
Infection, Inflammation, Immunology and Immunisation (I4) section of the European Society for Paediatric Research (ESPR)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal sepsis-induced cardiovascular dysfunction includes impaired myocardial function (which may be systolic and/or diastolic) and vasoregulatory failure (which may lead to vasodilation or vasoconstriction). The haemodynamic response in neonatal sepsis may therefore be hyperdynamic or hypodynamic, and the underlying pathophysiological mechanisms are heterogenous. The assessment of the neonate with sepsis and cardiovascular dysfunction is critical for targeted pathophysiology-based management. However, this assessment is challenging; it may include clinical features, echocardiography, electrocardiography and heart rate variability monitoring, non-invasive cardiac output monitoring (NICOM), near-infrared spectroscopy (NIRS) and biomarkers. Neonatologist performed echocardiography (NPE), in particular, can aid in the evaluation of the pathophysiological mechanism of cardiovascular dysfunction specific to each patient and further guide individualised management. IMPACT: WHAT DOES THIS ARTICLE ADD TO THE EXISTING LITERATURE?: This review provides an integrative overview of current methods for assessing cardiovascular dysfunction in neonatal sepsis, combining clinical evaluation with echocardiographic, electrocardiographic, non-invasive hemodynamic (NICOM, NIRS), and biomarker-based approaches to support early recognition and management.

Identifiers

PMID42056534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.