ArticlePediatric research2026
Adjunctive remote ischaemic postconditioning and hypothermia therapy in acute encephalopathy with biphasic seizures.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Accumulating safety data for remote ischemic conditioning in acute pediatric neurological conditions.Pediatric research · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a common form of acute infection-triggered encephalopathy in children. This study aimed to evaluate the safety and feasibility of remote ischaemic postconditioning (RIPoC) as an adjunct to therapeutic hypothermia in patients with AESD.
methodsIn this prospective, non-randomised study, patients treated in January 2021-July 2024 were compared with a historical control group treated in January 2017-December 2020. RIPoC (four cycles of 5-min inflation and 5-min deflation) was applied to the lower extremity at the initiation of therapeutic hypothermia. Adverse events were assessed between the RIPoC group (n = 15) and patients with therapeutic hypothermia in the control groups (n = 12). Neurological outcomes at 6-18 months post-onset were compared between the RIPoC group (n = 12) and patients with/without therapeutic hypothermia in the control groups (n = 13). Multivariate analyses were performed to identify predictors of favourable neurological outcomes.
resultsWhile the comparison of adverse events and neurological outcomes between groups did not show significant differences, multiple analysis suggested associations between a lower Tada score or RIPoC treatment and better outcomes.
conclusionRIPoC combined with therapeutic hypothermia appears safe and feasible in patients with AESD. IMPACT: Remote ischaemic postconditioning (RIPoC) was safely combined with hypothermia in paediatric patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). No coagulation, hemodynamic complications, or adverse events were observed. Multiple linear regression analysis suggested associations between a lower Tada score or RIPoC treatment and better outcomes in patients with AESD. This is the first report to examine the feasibility and safety of the RIPoC in paediatric central nervous system disease not directly related to ischaemia-reperfusion injury. Findings support future randomised controlled studies to confirm RIPoC as a possible adjunctive neuroprotective therapy in paediatric brain injury, particularly AESD.
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Registered trials
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