Evidence map›Paper›PMID 42056528›Full record

ArticleNature2026

Translation-dependent degradation of cas12 mRNA triggered by an anti-CRISPR.

Nicole D Marino, Alexander Talaie, Milan Gerovac, Jorge L Rodriguez, Andrew D Schmidt, Theresa J Astmann, Héloïse Carion, Anya Flood Taylor, Jessica Liliedahl, Surabhi Haniyur and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Nicole D MarinoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. ndmarino@upenn.edu.
Alexander TalaieDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0008-1444-5699
Milan GerovacHelmholtz Centre for Infection Research, Brunswick, Germany.ORCID http://orcid.org/0000-0002-6929-7178
Jorge L RodriguezDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Andrew D SchmidtDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Theresa J AstmannDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Héloïse CarionDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Anya Flood TaylorDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0004-6020-1952
Jessica LiliedahlDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Surabhi HaniyurDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0003-6914-327X
Kristi ZogaDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Matthew C JohnsonDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Leandro BuhlmannInstitute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0009-0000-1943-2813
Kuei-Ho ChenQuantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6541-0578
Sukrit SilasDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Li YupingDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Yang ZhangDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Danielle L SwaneyQuantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6119-6084
Jörg VogelInstitute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-2220-1404
Joseph Bondy-DenomyDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. Joseph.Bondy-Denomy@ucsf.edu.ORCID http://orcid.org/0000-0002-4909-9481

Funding

Uncovering the mechanism and role of a widespread anti-CRISPR-Cas9 proteinR01GM127489 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2018 to 2022
$1.7M
Discovery of novel phage-bacterial interactionsR00GM143476 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Nicole D. Marino · 2024 to 2026
$747k
Discovery of novel phage-bacterial interactionsK99GM143476 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARINO, NICOLE D. · 2021 to 2022
$200k
Discovery, Mechanism and Function of Type-V CRISPR-Cas InhibitorsF32GM133127 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARINO, NICOLE D. · 2019 to 2021
$148k
NIGMS NIH HHS F32 GM133127NIGMS NIH HHS K99 GM143476NIGMS NIH HHS R00 GM143476NIGMS NIH HHS R01 GM127489
6 · The paper itself

Abstract

Bacteria encode diverse defence systems, including CRISPR-Cas, to recognize and cleave the DNA of bacteriophages (phages) and other mobile genetic elements

Indexed as

CRISPR-Associated ProteinsCRISPR-Cas SystemsEndodeoxyribonucleasesProtein BiosynthesisRNA, MessengerRNA StabilityViral ProteinsBacterial ProteinsBacteriophagesConserved SequenceProtein DomainsRibosomesBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsEndodeoxyribonucleasesRNA, MessengerViral Proteins

Identifiers

PMID42056528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.