Evidence map›Paper›PMID 42056527›Full record

Trial reportNature2026

Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1.

Lambros Tselikas, Sandrine Susini, Matthieu Texier, Andrey Yurchenko, Emilie Routier, Mona Amini-Adle, Edi Tihic, Séverine Mouraud, François-Xavier Danlos, Samy Ammari and 20 more

Abstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase I
In one paragraph

Trial report in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Covalent tumor anchoring spatially orchestrates antitumor immunity.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Lambros Tselikas *INSERM CIC 1428, BIOTHERIS, Villejuif, France.
Sandrine Susini *INSERM CIC 1428, BIOTHERIS, Villejuif, France.ORCID http://orcid.org/0000-0002-2561-6528
Matthieu TexierGustave Roussy, Service de Biostatistiques et d'Epidémiologie (SBE), Université Paris Saclay, Villejuif, France.
Andrey YurchenkoINSERM U981, Gustave Roussy, Villejuif, France.ORCID http://orcid.org/0000-0002-2239-6902
Emilie RoutierGustave Roussy, Dermatologie, Département de Médecine Oncologique, Villejuif, France.
Mona Amini-AdleHospices Civils de Lyon, Département de Dermatologie, Lyon, France.
Edi TihicINSERM U1015, Laboratoire de Recherche Translationnelle en Immunothérapie (LRTI), Villejuif, France.
Séverine MouraudINSERM U1015, Laboratoire de Recherche Translationnelle en Immunothérapie (LRTI), Villejuif, France.ORCID http://orcid.org/0000-0003-3264-6298
François-Xavier DanlosINSERM CIC 1428, BIOTHERIS, Villejuif, France.
Samy AmmariGustave Roussy, Département d'Imagerie Médicale, Villejuif, France.
Thibault RaoultGustave Roussy, Service de Promotion d'Etudes Cliniques, DRC, Villejuif, France.ORCID http://orcid.org/0000-0003-4574-3978
Séverine RoyINSERM U981, Gustave Roussy, Villejuif, France.
Delphine BredelINSERM U1015, Laboratoire de Recherche Translationnelle en Immunothérapie (LRTI), Villejuif, France.
Siham FarhaneINSERM CIC 1428, BIOTHERIS, Villejuif, France.
Lydie CassardUniversité Paris-Saclay, Gustave Roussy, INSERM, Laboratoire d'Immunomonitoring en Oncologie US23, Biothérapies Innovantes U1363, Villejuif, F-94805, France.
Irma MolinaroGustave Roussy, Département de Biologie et Pathologie Médicale, Villejuif, France.
Alexander EggermontUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.
Jean-Charles SoriaUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.
Laurence ZitvogelUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.ORCID http://orcid.org/0000-0003-1596-0998
Christophe MassardUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.
Angelo PaciUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.ORCID http://orcid.org/0000-0002-4849-0825
Thierry de BaereINSERM CIC 1428, BIOTHERIS, Villejuif, France.ORCID http://orcid.org/0000-0002-4556-7663
Jean-Yves ScoazecUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.ORCID http://orcid.org/0000-0003-1604-6823
Nathalie ChaputUniversité Paris-Saclay, Gustave Roussy, INSERM, Laboratoire d'Immunomonitoring en Oncologie US23, Biothérapies Innovantes U1363, Villejuif, F-94805, France.ORCID http://orcid.org/0000-0003-2506-7853
Sergey NikolaevINSERM U981, Gustave Roussy, Villejuif, France.ORCID http://orcid.org/0000-0001-8587-2307
Nicolas MeyerCHU de Toulouse, Service d'Oncodermatologie, IUCT-O, Toulouse, France.
Céleste LebbéUniversité Paris Cité, AP-HP Dermato-oncologie et CIC, Institut du Cancer APHP nord, Paris, France.
Stéphane DalleHospices Civils de Lyon, Département de Dermatologie, Lyon, France.
Caroline RobertUniversité Paris Saclay, Faculty of Medicine, Villejuif, France.ORCID http://orcid.org/0000-0002-9493-0238
Aurélien MarabelleINSERM CIC 1428, BIOTHERIS, Villejuif, France. aurelien.marabelle@gustaveroussy.fr.ORCID http://orcid.org/0000-0002-5816-3019

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous administration of anti-CTLA4 with anti-PD1 provides durable tumour responses but causes severe treatment-related adverse events in patients with cancer

Indexed as

CTLA-4 AntigenIpilimumabMelanomaNivolumabProgrammed Cell Death 1 ReceptorAdministration, IntravenousFemaleHumansMaleMiddle AgedT-Lymphocytes, RegulatoryTreatment OutcomeCTLA-4 AntigenCTLA4 protein, humanIpilimumabNivolumabPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID42056527
PMCPMC13323097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.