Associations of 24-h urinary excretion of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease.

Sisi Xie, Aurélien Thomas, Belen Ponte, Daniel Ackermann, Menno Pruijm, Murielle Bochud, Pedro Marques-Vidal

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Sisi XieDepartment of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Office Bh10-642, Rue du Bugnon 46, 1011, Lausanne, Switzerland.

Aurélien ThomasFaculty Unit of Toxicology, University Center of Legal Medicine Lausanne-Geneva, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Belen PonteDivision of Nephrology and Hypertension, Department of Medicine, University Hospital of Geneva (HUG), Geneva, Switzerland.

Daniel AckermannDepartment of Nephrology and Hypertension, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

Menno PruijmService of Nephrology and Hypertension, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

Murielle BochudDepartment of Epidemiology and Health Systems, Unisanté, Lausanne, Switzerland.

Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Office Bh10-642, Rue du Bugnon 46, 1011, Lausanne, Switzerland. Pedro-Manuel.Marques-Vidal@chuv.ch.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 33CM30-124087

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a growing global health concern. Although certain elements have been implicated in CKD, evidence based on 24-h urinary excretion and kidney outcomes remains limited. Cross-sectional data from the SKIPOGH cohort (2008-2013) were used to assess 24-h urinary element excretion, estimated glomerular filtration rate (eGFR), and CKD. Associations were evaluated using multivariable regression, nonlinear modeling, mixture analysis, and fractional excretion. Among 923 participants (mean age 47.8 years, 52.0% female), higher 24-h urinary excretion of vanadium, chromium, cobalt, palladium, silver, cadmium, and mercury was positively associated with eGFR in multivariable analyses. Fractional excretion analyses showed associations consistent with differences in kidney handling. In addition, CKD was present in 67 participants (7.3%). Higher 24-h urinary excretion of copper and zinc was associated with increased odds of CKD, whereas urinary excretion of selenium, palladium, cadmium, and mercury was inversely associated with CKD, including after adjustment for plasma concentrations. After correction for multiple testing, associations for vanadium, chromium, and palladium with eGFR, and for copper and mercury with CKD, remained statistically significant. Several 24-h urinary element excretion measures were statistically associated with kidney function. Longitudinal studies are needed to clarify temporal relationships and underlying mechanisms.

Indexed as

Glomerular Filtration RateMetals, HeavyRenal Insufficiency, ChronicTrace ElementsAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedMetals, HeavyTrace ElementsChronic kidney diseaseGlomerular filtration rateMetals, heavyTrace elementsUrinary excretion

Identifiers

PMID42056484

DOI10.1038/s41598-026-51034-8

PMCPMC13319113

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