Evidence map›Paper›PMID 42056392›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.

Fernando Henríquez, Patricio Riquelme, Gonzalo Forno, Joaquín Migeot, Rodrigo Henríquez, Patricia Lillo, Daniela Thumala-Dockendorff, Cecilia Okuma, Cecilia González Campo, Michael Hornberger and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fernando HenríquezNeuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago, Chile.
Patricio RiquelmeNeuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago, Chile.
Gonzalo FornoNeuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago, Chile.
Joaquín MigeotLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Rodrigo HenríquezInterdisciplinary Center for Neuroscience (NeuroUC), Laboratory for Cognitive and Evolutionary Neuroscience (LANCE), Department of Neurology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Patricia LilloGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Daniela Thumala-DockendorffGeroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Cecilia OkumaInstitute of Neurosurgery, Dr. Alfonso Asenjo, Santiago, Chile.
Cecilia González CampoCognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Argentina.
Michael HornbergerClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Francisco AboitizInterdisciplinary Center for Neuroscience (NeuroUC), Laboratory for Cognitive and Evolutionary Neuroscience (LANCE), Department of Psychiatry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Andrea SlachevskyNeuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago, Chile.ORCID https://orcid.org/0000-0001-9854-9680

Funding

An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Circadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0M
Alzheimer's Association ALZ-RWD-26-1466627Alzheimer's Association SG-20-725707ANID/CIN CIN250068ANID Doctoral Scholarship 21211340ANID/FONDAP 15150012ANID/FONDECYT regular 1231839Bluefield Project to Cure Frontotemporal Dementia GRANT: Building Capacity for Frontotemporal Dementia Trial in ReDLatNIA NIH HHS R01 AG057234NIA NIH HHS R01AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01AG075775NIA NIH HHS R01 AG083799NIA NIH HHS R01AG083799TAU Consortium and Rainwater Charitable Foundation, GRANT: Multi-Partner Consortium for Dementia Research in Latin America
6 · The paper itself

Abstract

introductionFunctional decline in activities of daily living (ADL)-advanced (AADL), instrumental (IADL), and basic (BADL)-is a hallmark of Alzheimer's disease (AD). However, integrated clinical-neuroanatomical evidence on progression across the AD continuum remains limited, particularly in Latin American populations.

methodsWe studied 138 older adults with subjective cognitive complaints (SCCs), mild cognitive impairment (MCI), and Alzheimer's disease dementia (ADD). ADL domains were assessed using the Technology-Activities of Daily Living Questionnaire. Structural magnetic resonance imaging data were analyzed using voxel-based morphometry (VBM) to identify gray matter (GM) correlates of ADL performance.

resultsA hierarchical decline from AADL to IADL to BADL differentiated clinical stages. SCC and MCI differed mainly in AADL performance, whereas ADD showed decline across all domains. VBM revealed GM correlates consistent with this hierarchy, with distinct but partially overlapping substrates for each ADL domain. DISCUSSION: These findings underscore a diagnostically informative and anatomically organized progression of ADL decline.

Indexed as

Activities of Daily LivingAlzheimer DiseaseBrainAgedAged, 80 and overCognitive DysfunctionCohort StudiesDisease ProgressionFemaleGray MatterHumansLatin AmericaMagnetic Resonance ImagingMaleNeuropsychological TestsSurveys and Questionnairesactivities of daily livingAlzheimer's disease continuumbrain atrophyfunctional abilityneural correlatesvoxel‐based morphometry

Identifiers

PMID42056392
PMCPMC13128346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.