ArticleAnnals of biomedical engineering2026
Patient-Specific Constitutive Models Based on Biaxial and Microstructural Characterisation of Fresh Human Gastric Tissue.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAs obesity has reached pandemic proportions worldwide, improving technical solutions for its treatment requires robust planning and numerical modelling. Yet existing material models obtained from biaxial tensile test are scarce and based only on frozen human or porcine samples, without histological quantitative consideration. Our objective was to generate fresh-human biaxial data including microstructure orientation/dispersion and provide patient-specific material models suitable for biofidelic FE modelling.
methodsFundus and corpus samples of human stomach (10 sleeve-gastrectomy patients) underwent planar biaxial testing at two rates (0.1 and 1 mm·s⁻
resultsA consistent hierarchy emerged despite inter-patient variability with corpus stiffer than fundus, and longitudinal orientation stiffer than circumferential. Higher speed resulted in higher stress. In terms of safe characterisation limit (measured at 0.1 mm·s⁻
conclusionFresh-human, full-field biaxial data coupled to quantified collagen architecture yield specimen-level parameters and region-specific safe-stretch thresholds, enabling biofidelic, patient-specific FE simulations of gastric procedures and device-tissue interaction.
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