ArticleScientific reports2026
Genome-based analysis of Bacillus velezensis Bm3 isolated from a vulnerable dioxin-contaminated site in central Syria reveals mechanisms of dioxin degradation.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dioxin contamination represents a serious global environmental threat, particularly in developing and climate-vulnerable regions. This study evaluates the potential of Bacillus velezensis Bm3, isolated from a dioxin-contaminated site in central Syria, for the aerobic biodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Quantitative analyses demonstrated a strong biodegradative capacity, with 71% and 76% of the initial TCDD concentration removed after 5 and 6 weeks, respectively. Whole-genome sequencing revealed a 5.29 Mbp genome encoding 5411 predicted proteins, providing a solid genetic basis for this activity. A two-step degradation pathway is proposed, initiated by cytochrome P450-mediated hydroxylation of TCDD to dihydroxy-hydrodibenzo-p-dioxin, followed by conversion to the key intermediate catechol. This compound is subsequently cleaved by catechol 2,3-dioxygenase, yielding acetaldehyde and pyruvate. Gene expression and protein accumulation analyses supported this mechanism, showing strong induction of a specific cytochrome P450 isoform (CYPBM3_v1_ua3131) and cat-2,3-diox transcripts. These findings identify B. velezensis Bm3 as a promising candidate for TCDD bioremediation in warm, dry environments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.