Evidence map›Paper›PMID 42056258›Full record

ArticleCancer gene therapy2026

YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro.

Jingying Su, Jihan Qi, Binhua Xu, Jiaxin Wang, Ram Prasad Chaulagain, Hongliang Chen, Ning Li, Xinyu Jiang, Lingyi Xu, Fengchun Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingying Su *Department of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jihan Qi *Department of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Binhua XuDepartment of Endocrinology, Harbin the First Hospital, Harbin, China.
Jiaxin WangDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ram Prasad ChaulagainDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongliang ChenDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ning LiDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xinyu JiangDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Lingyi XuDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Fengchun LiDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Wenli MaoDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Shizhu JinDepartment of Gastroenterology and Hepatology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. drshizhujin@hrbmu.edu.cn.ORCID http://orcid.org/0000-0003-3613-0926

Funding

Xinjiang Production and Construction Corps 2023AB018-01
6 · The paper itself

Abstract

Gastric cancer (GC) continues to be a major contributor to global cancer mortality, underscoring the need to elucidate its molecular mechanisms to develop effective therapies. Cuproptosis, a copper-dependent form of cell death, exhibits tumor-suppressive effects in GC. Clinical specimens revealed elevated expression of solute carrier family 39 member 4 (SLC39A4) in GC tissues, correlating with poor prognosis. However, the role of SLC39A4 in GC remains unclear. Using lentiviral transduction in AGS and MKN-45 cell lines, we established stable monoclonal strains with SLC39A4 overexpression and knockdown for functional studies. SLC39A4 promotes GC cell proliferation both in vitro and in vivo. CuCl

Indexed as

Cation Transport ProteinsCuproptosisRNA-Binding ProteinsStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceSignal TransductionXenograft Model Antitumor AssaysCation Transport ProteinsRNA-Binding ProteinsSLC39A4 protein, human

Identifiers

PMID42056258
PMCPMC13364648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.