Evidence map›Paper›PMID 42056135›Full record

ArticleScientific data2026

Whole genome DNA methylation atlas of the scallop Patinopecten yessoensis.

Runyi Zhang, Danyang Wang, Sinuo Liu, Lisui Bao, Lingling Zhang, Shi Wang, Naina Hu, Shanshan Lian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Runyi Zhang *Fang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Danyang Wang *Fang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Sinuo LiuFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Lisui BaoFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Lingling ZhangFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Shi WangFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Naina HuFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China. hunaina@ouc.edu.cn.
Shanshan LianFang Zongxi Center for Marine Evo-Devo, MOE Key Laboratory of Marine Genetics and Breeding & Shandong Key Laboratory of Marine Seed Industry, College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China. lianshanshan@ouc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation, a fundamental epigenetic mechanism in eukaryotes, remains inadequately studied in the second-largest animal phylum, Mollusca. This gap persists due to a lack of comprehensive cross-tissue methylome data, which has hindered a deeper understanding of its regulatory roles in various organs in molluscs. To address this, we utilized the Yesso scallop (Patinopecten yessoensis), which retains most of the ancestral bilaterian gene families as a model system. Employing whole-genome bisulfite sequencing (WGBS), we constructed a high-resolution DNA methylation atlas spanning nine organs, including shell, striated muscle, mantle, hepatopancreas, blood, kidney, smooth muscle, gill, and foot. This approach produced 4.9 billion high-quality clean reads with robust biological reproducibility. Clustering analysis indicated that muscle tissues and blood share notable epigenetic similarities. In contrast, the shell displayed distinct methylation landscapes, likely reflecting its highly specialized functions in hematopoiesis and stem cell maintenance. Our data offers new perspectives on the involvement of DNA methylation in organ specialization in molluscs.

Indexed as

DNA MethylationGenomePectinidaeAnimalsDatasets as TopicEpigenesis, Genetic

Identifiers

PMID42056135
PMCPMC13333978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.