Evidence map›Paper›PMID 42056114›Full record

ArticleNature communications2026

The mannose receptor on sinusoidal lining cells mediates two-step bacterial clearance in the human spleen.

Neama Alnabati, Francesco Flandi, Tareq Al Saoudi, Giulia Cattabriga, Talia Richardson, Alessia Gennai, Daniele Ghezzi, Ryan G Hames, John Isherwood, Trisha Kanani and 22 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04620824 (TIssue Models for Invasive Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04620824 unknown statusnot on this map

TIssue Models for Invasive Disease (TIMID)

TypeobservationalSponsorUniversity of LeicesterRan2018 to 2025Enrolled24ConditionsSpleen, Septic
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Neama Alnabati *College of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.
Francesco Flandi *Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Tareq Al SaoudiDepartment of Hepato-Pancreato-Biliary Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Giulia CattabrigaDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Talia RichardsonCollege of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.
Alessia GennaiDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Daniele GhezziDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Ryan G HamesCollege of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.
John IsherwoodDepartment of Hepato-Pancreato-Biliary Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Trisha KananiDepartment of Hepato-Pancreato-Biliary Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Zydrune JasiunaiteCollege of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.
Shiying TangCollege of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.
Giuliana GerminarioIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Giorgia RadiDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Francesca RizzoIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Katrin SchilcherCollege of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.
Christopher D BaylissCollege of Life Sciences, School of Biological and Biomedical Sciences, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-5564-2145
Romina CamilliIstituto Superiore di Sanità, Roma, Italy.
Marco CapriniDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-8542-9388
Carola ParolinDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-1536-9276
Stefano FediDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Wen Y ChungDepartment of Hepato-Pancreato-Biliary Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.ORCID http://orcid.org/0000-0003-0970-0639
Giuseppe GarceaDepartment of Hepato-Pancreato-Biliary Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Enrico GiampieriIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-2269-2338
Gastone CastellaniIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0003-4892-925X
Kornelis StraatmanAdvanced Imaging Facility, University of Leicester, Leicester, UK.ORCID http://orcid.org/0000-0002-9812-492X
Stefano BrunoDepartment of Food and Drug, University of Parma, Parma, Italy.
Claudia TrappettiDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0001-8272-0068
Matteo RavaioliIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Ashley R DennisonDepartment of Hepato-Pancreato-Biliary Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Luisa Martinez-PomaresSchool of Life Sciences, University of Nottingham, Nottingham, UK. luisa.m@nottingham.ac.uk.ORCID http://orcid.org/0000-0002-2331-127X
Marco R OggioniDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. marcorinaldo.oggioni@unibo.it.ORCID http://orcid.org/0000-0003-4117-793X

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) 202089LLEHMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) P2022M8KYEMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PE00000007RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V01465X/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) RM32G0178B7
6 · The paper itself

Abstract

The human spleen plays a critical role in clearing bacteria from the bloodstream, particularly during septicaemia; yet the cellular mechanisms underlying this function remain poorly defined. Using a dual translational approach including ex vivo perfusion of human spleens and splenic primary cell cultures, we identify a previously unrecognised division of tasks in splenic antibacterial defence. In the human splenic red pulp, sinusoidal lining cells capture and retain bacteria via the CD206 mannose receptor. Subsequently, the bactericidal activity by red pulp macrophages involves the scavenger receptor MARCO. This two-step process ensures efficient removal of encapsulated pathogens as inhibition of CD206 receptor impacted not only Streptococcus pneumoniae killing, independent of the capsular serotype, but also on Klebsiella pneumoniae and Escherichia coli revising the mechanism of pathogen clearance in the human spleen. Trial registration: REC 18/EM/0057 (NCT04620824) and CE: 668/2023/Sper/AOU.

Indexed as

Lectins, C-TypeMannose-Binding LectinsReceptors, Cell SurfaceSpleenEscherichia coliFemaleHumansKlebsiella pneumoniaeMacrophagesMaleMannose ReceptorReceptors, ImmunologicStreptococcus pneumoniaeLectins, C-TypeMannose-Binding LectinsMannose ReceptorReceptors, Cell SurfaceReceptors, Immunologic

Identifiers

PMID42056114
PMCPMC13421466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.