Evidence map›Paper›PMID 42056090›Full record

ArticleNature communications2026

RNA targeting therapy for a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death.

Sean R Golinski, Karla Soriano, Alex C Briegel, Madeline C Burke, Sheng Tang, Gemma L Carvill, Emma Sherrill, Claudia Lentucci, Timothy W Yu, Tojo Nakayama and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. State-of-the-art gene therapy in epilepsy.Current opinion in neurology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sean R GolinskiNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Karla SorianoNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Alex C BriegelNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Madeline C BurkeNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Sheng TangNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Gemma L CarvillNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4945-3628
Emma SherrillDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
Claudia LentucciDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
Timothy W YuDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2988-7701
Tojo NakayamaDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2110-6878
Ruilong HuNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Richard S SmithNorthwestern University, Feinberg School of Medicine, Chicago, IL, USA. Richard.smith@northwestern.edu.ORCID http://orcid.org/0000-0003-1937-6529

Funding

Perinatal brain therapeutics: a high throughput biology approach to build next generation RNA precision medicinesDP2NS148744 · NINDS · NORTHWESTERN UNIVERSITY · PI SMITH, RICHARD S · 2025 to 2025
$1.4M
Sodium Channel Dysfunction in Altered Brain DevelopmentR01NS140046 · NINDS · NORTHWESTERN UNIVERSITY · PI Richard S Smith · 2025 to 2026
$1.3M
Role for ion conducting proteins in cortical malformation diseasesR00NS112604 · NINDS · NORTHWESTERN UNIVERSITY · PI SMITH, RICHARD S · 2023 to 2025
$715k
NINDS NIH HHS DP2 NS148744NINDS NIH HHS R01 NS140046U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R00NS112604
6 · The paper itself

Abstract

Dysfunction of the sodium-activated potassium channel K

Indexed as

EpilepsyNerve Tissue ProteinsPotassium Channels, Sodium-ActivatedAnimalsBrainFemaleHumansInfant, NewbornMaleNeuronsOligonucleotides, AntisenseKCNT1 protein, humanNerve Tissue ProteinsOligonucleotides, AntisensePotassium Channels, Sodium-Activated

Identifiers

PMID42056090
PMCPMC13333874

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.