Evidence map›Paper›PMID 42056069›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Undiagnosed dementia and mortality among older adults in the United States and Brazil: A cross-national cohort study.

Márlon Juliano Romero Aliberti, Thiago J Avelino-Silva, Kenneth E Covinsky, Kenneth Lam, Sei J Lee, Laiss Bertola, Cleusa P Ferri, Maria Fernanda Lima-Costa, Juliana Vaz de Melo Mambrini, Andrew Christopher Claro Miguel and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Márlon Juliano Romero AlibertiLaboratorio de Investigacao Medica em Envelhecimento (LIM-66) Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0001-7467-1745
Thiago J Avelino-SilvaLaboratorio de Investigacao Medica em Envelhecimento (LIM-66) Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Kenneth E CovinskyDivision of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Kenneth LamDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Sei J LeeDivision of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Laiss BertolaLaboratorio de Investigacao Medica em Envelhecimento (LIM-66) Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Cleusa P FerriDepartment of Psychiatry, Escola Paulista de Medicina, Departamento de Psiquiatria, Universidade Federal de São Paulo, São Paulo, Brazil.
Maria Fernanda Lima-CostaNúcleo de Estudo em Saúde Pública e Envelhecimento (NESPE) da Universidade Federal de Minas Geraise da Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Juliana Vaz de Melo MambriniNúcleo de Estudo em Saúde Pública e Envelhecimento (NESPE) da Universidade Federal de Minas Geraise da Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
Andrew Christopher Claro MiguelDepartment of Psychiatry, Escola Paulista de Medicina, Departamento de Psiquiatria, Universidade Federal de São Paulo, São Paulo, Brazil.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Claudia Kimie SuemotoLaboratorio de Investigacao Medica em Envelhecimento (LIM-66) Servico de Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Funding

Integrting Information About Aging SurveysR01AG030153 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, Alden L. Gross · 2007 to 2026
$41.7M
Preparing For What Is Next With Aducanumab In Real World SettingsR33AG057806 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Christopher Barrett Bowling, Ana Roman Quinones · 2018 to 2026
$9.0M
RESEARCH TRAINING IN GERIATRIC MEDICINET32AG000212 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 1991 to 2026
$7.7M
Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
Prognostic Indices for Hospitalized Older Adults with and without Alzheimer’s Disease and Related DementiasR01AG079982 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Sei Lee, Alexander Keliimoeanu Smith · 2023 to 2026
$3.1M
Biomarkers of neurodegeneration in the US and India: A cross-national evaluation of the biological underpinnings of ADRDRF1AG088003 · NIA · JOHNS HOPKINS UNIVERSITY · PI CRIMMINS, EILEEN M, GROSS, ALDEN L. · 2024 to 2024
$2.4M
Mentoring Patient-Oriented Research to Individualize Care for Hospitalized Older Adults with and without Alzheimer's Disease and Related DementiasK24AG066998 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sei Lee · 2021 to 2026
$1.1M
Alzheimer's Association AARG-20-678884Conselho Nacional de Desenvolvimento Científico e Tecnológico 421262/2025-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/03917-7NIA NIH HHS K24 AG066998NIA NIH HHS R01AG0079982NIA NIH HHS R01 AG030153NIA NIH HHS R01 AG070953NIA NIH HHS R01 AG079982NIA NIH HHS R33 AG057806NIA NIH HHS RF1 AG088003NIA NIH HHS T32 AG000212
6 · The paper itself

Abstract

introductionCross-national evidence on undiagnosed dementia and its prognostic implications remains limited. We compared the proportion of undiagnosed dementia, associated factors, and mortality in the United States and Brazil.

methodsThis population-based cohort study included adults aged ≥ 65 years from the 2016 US Health and Retirement Study (n = 9,539) and the 2015-2016 Brazilian Longitudinal Study of Aging (n = 3603), followed for mortality through 2020. Dementia was classified as no dementia, undiagnosed dementia, or diagnosed dementia using harmonized cognitive, functional, and informant measures.

resultsThe proportion of undiagnosed dementia was higher in Brazil (76.1%) than in the United States (45.1%). Undiagnosed dementia was associated with increased 4-year mortality compared with no dementia in both countries. It was linked to younger age and absence of memory complaints, with marked socioeconomic and healthcare disparities in Brazil. DISCUSSION: Undiagnosed dementia is common and associated with increased mortality, identifying a vulnerable population missed by current diagnostic pathways.

Indexed as

DementiaAgedAged, 80 and overBrazilCohort StudiesFemaleHumansLongitudinal StudiesMaleUnited Statescross‐national studiesdementiadiagnosishealth equitymortalityolder adultsprognosisundiagnosed dementia

Identifiers

PMID42056069
PMCPMC13128339

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.