ArticleHead & neck2026
Pattern of Progression of Oral Potentially Malignant Disorders From Real-World Data: A 24-Year Study.
Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
backgroundOral potentially malignant disorder (OPMD) prognostication is limited by uncertainty of which lesions will progress and the aggressiveness of lesion progression. We defined patterns and kinetics of progression in a large cohort of OPMD subjected to serial clinical and histologic examinations.
methodsThis 24-year study evaluated the pattern of disease progression in 668 patients with 1313 OPMDs.
resultsThe disease progression pattern was grouped as (a) non-progressive (82.5%), (b) progressive, where initial low-grade dysplasia advanced to high-grade dysplasia in subsequent lesions (5.8%), and (c) transformed, where dysplastic lesions transformed into squamous cell carcinoma (11.7%). Progression showed aggressive (< 2 years) and indolent (> 2 years) patterns. An aggressive course occurred in 48.3% of progressive and 57.6% of transformed lesions. Progression was associated with high-grade lesions, floor of mouth and palate subsites, and tobacco and alcohol use.
conclusionsThe data from this study may be used to develop a risk-stratified approach for OPMD management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.