Evidence map›Paper›PMID 42055938›Full record

ArticleJournal of medicinal chemistry2026

Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases.

Alessio Nocentini, Simone Giovannuzzi, Vincenzo Alterio, Alessandro Bonardi, Rudolfs Barons, Raivis Zalubovskis, Wagdy M Eldehna, Rossella Aronne, Davide Esposito, Enrico Luchinat and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alessio NocentiniNEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0003-3342-702X
Simone GiovannuzziNEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0002-0669-7481
Vincenzo AlterioInstitute of Biostructures and Bioimaging, National Research Council, Napoli 80145, Italy.ORCID 0000-0002-0162-1656
Alessandro BonardiNEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino 50019, Italy.
Rudolfs BaronsLatvian Institute of Organic Synthesis, Riga LC-1006, Latvia.
Raivis ZalubovskisLatvian Institute of Organic Synthesis, Riga LC-1006, Latvia.ORCID 0000-0002-9471-1342
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0001-6996-4017
Rossella AronneDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena 53100, Italy.ORCID 0009-0008-3513-8188
Davide EspositoInstitute of Biostructures and Bioimaging, National Research Council, Napoli 80145, Italy.
Enrico LuchinatCERM - Magnetic Resonance Center, University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0003-4183-4311
Giuseppina De SimoneInstitute of Biostructures and Bioimaging, National Research Council, Napoli 80145, Italy.
Gianluca BartolucciNEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0002-5631-8769
Paola GratteriNEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0002-9137-2509
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena 53100, Italy.ORCID 0000-0003-2398-1254
Claudiu T SupuranNEUROFARBA Department, Section of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino 50019, Italy.ORCID 0000-0003-4262-0323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphocoumarins and a first-in-class unsubstituted phosphoquinolinone are disclosed as previously unrecognized carbonic anhydrase (CA) inhibitors, displaying multimodal inhibition within a tunable coumarin-like scaffold. Acidic phosphocoumarins display inhibition of physiologically relevant human CAs, particularly tumor-associated isoforms IX and XII (K

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesCoumarinsProdrugsQuinolonesAntineoplastic AgentsDrug DiscoveryHumansStructure-Activity RelationshipAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCoumarinsProdrugsQuinolones

Identifiers

PMID42055938
PMCPMC13181790

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.