Evidence map›Paper›PMID 42055818›Full record

ArticleChemMedChem2026

Synthesis of 2-Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti-Angiogenesis Properties.

Yi-Ting Liu, Cheng-Ta Lai, Shih-Wei Wang, Shan-Chi Liu, Yi-Lin Hwang, Yi-Chen Tsai, Chi-Yeh Lee, Yu-Wei Lai, Juei-Yu Yen, Po-Chuan Wang and 1 more

Abstract read
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi-Ting LiuSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.
Cheng-Ta LaiDepartment of Medicine, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.
Shih-Wei WangGraduate Institute of Biomedical Sciences, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.
Shan-Chi LiuGraduate Institute of Biomedical Sciences, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.
Yi-Lin HwangSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.
Yi-Chen TsaiSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.
Chi-Yeh LeeSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.
Yu-Wei LaiCenter of General Education, University of Taipei, Taipei City, Taiwan.
Juei-Yu YenGraduate Institute of Biomedical Sciences, College of Medicine, MacKay Medical University, New Taipei City, Taiwan.
Po-Chuan WangDepartment of Gastroenterology, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan.ORCID https://orcid.org/0000-0002-8521-4811
Hsueh-Yun LeeSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei City, Taiwan.ORCID https://orcid.org/0000-0001-6683-0726

Funding

MacKay Memorial Hospital MMH-HB-11106MacKay Memorial Hospital MMH-HB-11205National Science and Technology Council NSTC113-2320-B-038-054-MY3Taipei City Hospital TPCH-113-08
6 · The paper itself

Abstract

This study synthesized a series of C2 and N1-substituted benzimidazole hydroxamic acid (6-19) as HDAC inhibitors. Among them, most of 2-aryl(alkyl)benzimidazole hydroxamic acids (11-16) exhibited HDAC6 activity and slight HDAC1 (or HDAC2) activity. In addition, they also showed anti-angiogenic activity and inhibited the growth of tested cancer cells. For instance, compound 13 has a GI

Indexed as

Angiogenesis InhibitorsAntineoplastic AgentsBenzimidazolesHistone Deacetylase InhibitorsHydroxamic AcidsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHistone DeacetylasesHumansMolecular StructureStructure-Activity RelationshipAngiogenesis InhibitorsAntineoplastic AgentsBenzimidazolesHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic Acidsanti‐angiogenesisbenzimidazole hydroxamic acidsHDAC

Identifiers

PMID42055818
PMCPMC13128345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.