Evidence map›Paper›PMID 42055623›Full record

ArticleCancer genomics & proteomics

Integrated Proteomics Reveal ALDH1A1 as an Oncogenic Driver and Regulatory Hub in Hepatocellular Carcinoma.

Hanxun Yue, Zenan Hu, Guozhi Wu, Renpeng Li, N A Jiang, Y A Zheng, Yuping Wang, Yongning Zhou

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Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hanxun YueThe First Clinical Medical College, Lanzhou University, Lanzhou, P.R. China.
Zenan HuDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, P.R. China; zhouyn@lzu.edu.cn huzn@lzu.edu.cn.
Guozhi WuThe First Clinical Medical College, Lanzhou University, Lanzhou, P.R. China.
Renpeng LiThe First Clinical Medical College, Lanzhou University, Lanzhou, P.R. China.
N A JiangTongzhou Center for Disease Control and Prevention, Nantong, P.R. China.
Y A ZhengThe First Clinical Medical College, Lanzhou University, Lanzhou, P.R. China.
Yuping WangDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, P.R. China.
Yongning ZhouDepartment of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, P.R. China; zhouyn@lzu.edu.cn huzn@lzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAlthough aldehyde dehydrogenases 1 family member A1 (ALDH1A1) has been extensively studied in cancer, its role in hepatocellular carcinoma (HCC) remains poorly understood. This study was designed to characterize the expression pattern and functional roles of ALDH1A1 in HCC, and to further investigate its underlying molecular mechanisms using integrated proteomic analysis. MATERIALS AND

methodsThis study performed a pan-cancer analysis of ALDH1A1 expression, followed by validation of its expression levels in HCC tissue samples and cell lines. The expression of ALDH1A1 was manipulated using small interfering RNAs and lentiviral vector in HCC cell lines. And then the proliferation, migration, invasion, and tumorigenicity of HCC cells were observed

resultsALDH1A1 was highly expressed in HCC tissues but exhibited notable expression heterogeneity among HCC cell lines. Functionally, ALDH1A1 promoted the proliferation, migration, and tumorigenicity of HCC cells, while suppressing apoptosis and modestly attenuates invasion. Quantitative proteomic and phosphoproteomic analyses revealed that ALDH1A1 profoundly reshaped both protein expression and phosphorylation landscapes in HCC. Furthermore, we validated that ALDH1A1 positively regulates the expression of DMPK, PCMTD2, VAMP4, ARHGAP19, NOL4L, and ST7, while suppressing SLC31A1, DSTYK, CYP4F12, GPNMB expression. Rescue experiments indicated that ALDH1A1 may promote HCC

conclusionALDH1A1 acts as an oncogenic driver and regulatory hub in HCC.

Indexed as

Aldehyde Dehydrogenase 1 FamilyCarcinoma, HepatocellularLiver NeoplasmsProteomicsRetinal DehydrogenaseAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanRetinal DehydrogenaseALDH1A1HCChepatocellular carcinomaphosphoproteomicsproteomics

Identifiers

PMID42055623
PMCPMC13133839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.