Evidence map›Paper›PMID 42055592›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026

Oscillometry for the diagnosis of asthma in children: a systematic review.

Senali Y Seneviratne, Saxon Law-Gleen, Jonathan Broomfield, Pip Divall, Pooja Devani, Francine M Ducharme, Erol A Gaillard

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Senali Y SeneviratneDepartment of Respiratory Sciences, Leicester NIHR Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0001-5946-3526
Saxon Law-GleenDepartment of Respiratory Sciences, Leicester NIHR Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester, UK.
Jonathan BroomfieldDepartment of Respiratory Sciences, Leicester NIHR Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester, UK.
Pip DivallUniversity Hospitals of Leicester NHS Trust, Leicester, UK.
Pooja DevaniDepartment of Respiratory Sciences, Leicester NIHR Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester, UK.
Francine M DucharmeDepartments of Paediatric and of Social and Preventive Medicine, University of Montréal, Montréal, QC, Canada.ORCID https://orcid.org/0000-0001-5096-0614
Erol A GaillardDepartment of Respiratory Sciences, Leicester NIHR Biomedical Research Centre (Respiratory theme), University of Leicester, Leicester, UK eag15@leicester.ac.uk.ORCID https://orcid.org/0000-0003-0996-8133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiagnosing asthma in children and young people (CYP) remains challenging. Oscillometry is a promising tool and is feasible from 2 years of age. European Respiratory Society (ERS) technical standards and bronchodilator response (BDR) oscillometry thresholds have been published, but diagnostic accuracy is not established.

methodsWe systematically reviewed studies comparing oscillometry and spirometry in CYP under investigation for asthma. Reference standards were positive BDR or positive methacholine challenge test (MCT). Primary aims were to investigate the sensitivity and specificity of current ERS oscillometry thresholds (>40% decrease in resistance at 5 Hz (

results11 studies were included; six (n=992 CYP) utilised BDR and five (n=531 CYP) MCT as reference standard. Meta-analysis was not possible due to heterogeneity of results reported. In two studies using current ERS BDR thresholds, zero sensitivity and high specificity (>85%) were observed. In weighted regression analyses of BDR studies, a 17.0% decrease in resistance at 5-6 Hz had sensitivity and specificity of 71.6% (95% CI 69.7-73.7%); a 20.2% increase in

conclusionCurrently recommended ERS thresholds for oscillometry BDR have low sensitivity. Proposed thresholds for defining positive BDR and MCT by oscillometry require prospective validation and adoption of standards for measuring and reporting oscillometry parameters in future diagnostic comparative studies.

Indexed as

AsthmaLungOscillometryAdolescentBronchial Provocation TestsChildChild, PreschoolHumansPredictive Value of TestsReproducibility of ResultsSensitivity and SpecificitySpirometry

Identifiers

PMID42055592
PMCPMC13126124

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