Evidence map›Paper›PMID 42054995›Full record

ArticleCell2026

Spatial organization and detection of social odors in mouse primary olfactory system.

Bogdan Bintu, Yoh Isogai, Ignatius Jenie, Xiaowei Zhuang, Catherine Dulac

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Bogdan BintuDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA. Electronic address: bbintu@health.ucsd.edu.
Yoh IsogaiDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA; Allen Institute for Neural Dynamics, Seattle, WA 98109, USA.
Ignatius JenieDepartment of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Xiaowei ZhuangDepartment of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Department of Physics, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: zhuang@chemistry.harvard.edu.
Catherine DulacDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: dulac@fas.harvard.edu.

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5M
Microcircuits underlying murine parental behaviorR01HD082131 · NICHD · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 2015 to 2024
$3.5M
Systems-Level and in Situ Transcriptomics Deconstruction of Neural Circuits Underlying Sensorimotor Transformation in an Innate BehaviorR01NS116593 · NINDS · HARVARD UNIVERSITY · PI DULAC, CATHERINE, MURTHY, VENKATESH N · 2023 to 2024
$2.7M
High-throughput imaging of 3D chromatin regulation events in the nervous systemDP5OD031878 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BINTU, BOGDAN · 2021 to 2025
$2.0M
NICHD NIH HHS R01 HD082131NIH HHS DP5 OD031878NIMH NIH HHS U19 MH114821NINDS NIH HHS R01 NS116593
6 · The paper itself

Abstract

The detection of olfactory cues is essential to signal food, predators, and social encounters. To determine how the sensory detection of physiologically relevant odors is systematically mapped into the mouse primary olfactory system, we used multiplexed error-robust fluorescent in situ hybridization (MERFISH) to construct a molecular atlas of olfactory receptor (OR) expression in the main olfactory epithelium (MOE) and olfactory bulb (OB). We comprehensively quantified the expression of the mouse OR repertoire and uncovered stereotypical gradients of sensory neuron distribution in the MOE along two axes, central-to-peripheral and apical-to-basal. Projections of sensory neurons mirror these two MOE gradients along the dorsal-ventral and anterior-posterior axes of the OB, respectively. Integration with sequencing data revealed candidate signaling molecules underlying this spatial organization. Co-imaging OR and activity marker expression identified distinct spatial domains of sensory responses in the MOE and OB, providing a topographical basis for olfactory responses to ethologically relevant odors.

Indexed as

OdorantsOlfactory BulbOlfactory Receptor NeuronsAnimalsFemaleGene Expression RegulationIn Situ Hybridization, FluorescenceMaleMiceReceptors, OdorantSmellReceptors, Odorantolfactory bulbolfactory epitheliumolfactory receptorssensory detectionsocial odorsspatial transcriptomics

Identifiers

PMID42054995
PMCPMC13138485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.