Evidence map›Paper›PMID 42054667›Full record

ReviewJournal of immunology research2026

A Hidden Checkpoint: Bidirectional pH Remodeling of the Immunological Synapse in Cancer, Methods, and Therapeutic Opportunities.

Aurélie Guillemette, Eva Gez, Sofia Titah, Yasmine Touil

Abstract readReview
In one paragraph

Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Recent progress in small molecules targeting the acidic tumor microenvironment.Journal of enzyme inhibition and medicinal chemistry · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aurélie GuillemettePERSTIM Lab, CRCLille, Inserm U1366, CNRS UMR9020, ONCOLille, University of Lille, Institut Pasteur Lille (IPL), CHU Lille, F-59000, Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0002-3422-3689
Eva GezPERSTIM Lab, CRCLille, Inserm U1366, CNRS UMR9020, ONCOLille, University of Lille, Institut Pasteur Lille (IPL), CHU Lille, F-59000, Lille, France, chru-lille.fr.ORCID https://orcid.org/0009-0008-8518-3868
Sofia TitahPERSTIM Lab, CRCLille, Inserm U1366, CNRS UMR9020, ONCOLille, University of Lille, Institut Pasteur Lille (IPL), CHU Lille, F-59000, Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0003-4892-6817
Yasmine TouilPERSTIM Lab, CRCLille, Inserm U1366, CNRS UMR9020, ONCOLille, University of Lille, Institut Pasteur Lille (IPL), CHU Lille, F-59000, Lille, France, chru-lille.fr.ORCID https://orcid.org/0000-0002-2286-960X

Funding

INCAINCA_18477Institut National de la Santé et de la Recherche MédicaleLigue Contre le CancerUniversité de Lille
6 · The paper itself

Abstract

The immunological synapse (IS) is a nanoscale platform that coordinates T cell activation, cytoskeletal polarization, Ca

Indexed as

Immunological SynapsesNeoplasmsAnimalsCalcium SignalingHumansHydrogen-Ion ConcentrationLymphocyte ActivationT-LymphocytesTumor Microenvironmentacidic pHcalcium signalingimmune synapseimmunotherapymethodological approaches

Identifiers

PMID42054667
PMCPMC13128168

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.