Observational studyAnnals of cardiac anaesthesia2026
Chronic Preoperative B-blocker Therapy and Postoperative Atrial Fibrillation after Elective Ascending Aortic Surgery.
Observational study in Annals of cardiac anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundPostoperative atrial fibrillation (POAF) is a frequent complication following cardiac surgery and is associated with increased morbidity and mortality. Although b-blockers are commonly used for POAF prevention, their efficacy in patients undergoing elective surgery of the ascending aorta remains unclear.
aimsWe aimed to evaluate the impact of chronic preoperative b-blocker therapy on the occurrence of POAF in patients undergoing elective ascending thoracic aortic surgery. SETTINGS AND
designThis single-center, retrospective observational study included adult patients who underwent elective surgical aneurysm repair of the ascending aorta between 2012 and 2021. MATERIALS AND
methodsPatients with a documented history of paroxysmal, persistent, or permanent atrial fibrillation were excluded. Acute aortic dissection cases were also excluded. STATISTICAL ANALYSIS: Associations between preoperative b-blockers therapy and POAF, as well as postoperative clinical outcomes, were assessed using Chi-square tests and independent-samples t -tests.
resultsA total of 214 patients were included in the analysis. POAF occurred in 46% of patients. Chronic preoperative b-blocker therapy was not significantly associated with the development of POAF ( P = 0.058). Among postoperative outcomes, stroke was significantly more frequent in patients who developed POAF ( P = 0.026), whereas no significant associations were observed with acute kidney injury, renal replacement therapy, reintubation, or in-hospital mortality.
conclusionsIn patients undergoing elective ascending aortic surgery, chronic preoperative b-blocker therapy was not significantly associated with a reduced incidence of POAF. These findings suggest that POAF risk in aortic surgery may be influenced by factors beyond conventional pharmacological prophylaxis.
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