ArticleAnnals of cardiac anaesthesia2026
Thrombocytopenia After Cardiac Surgery: A Single-Center Retrospective Study.
Article in Annals of cardiac anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPostoperative thrombocytopenia is a frequent complication in cardiac surgery, associated with increased morbidity and mortality. Our study aimed to describe platelet count after cardiac surgery and identify predictors of postoperative thrombocytopenia.
methodsWe conducted a retrospective, single-center study including 519 adult patients who underwent cardiac surgery without operative platelet transfusion. The primary outcome was the incidence of postoperative thrombocytopenia, defined using three thresholds: <150 G/L, <100 G/L, and <50 G/L. Platelet counts were recorded daily from preoperative day to postoperative day 7. Independent predictors were identified using multivariate logistic regression for a threshold of 100 G/L.
resultsThrombocytopenia < 150 G/L occurred in 306 patients (59%), <100 G/L in 92 (18%), and < 50 G/L in 35 (7%). The incidence of thrombocytopenia depended on the type of surgery ( P < 0.0001). Mitral valve surgery, ascending aorta procedures, and the use of sutureless aortic valve prostheses were associated with increased thrombocytopenia rates. Platelet counts were higher in patients who have had off-pump coronary surgery within the first five days ( P < 0.0001). Five independent predictors were identified: older age ( P = 0.022), lower baseline platelet count ( P < 0.0001), higher creatinine ( P = 0.04), operative transfused units of red blood cells ( P = 0.015), and higher autotransfusion volume ( P = 0.02). The model using only preoperative variables achieved an AUC of 0.83. Finally, thrombocytopenia <100 G/L was associated with more blood loss ( P = 0.001), more postoperative transfusions ( P < 0.0001), and longer intensive care unit stay ( P = 0.001).
conclusionOur study differentiates pre- and perioperative risk factors for thrombocytopenia in cardiac surgery to define a targeted, individualized platelet management strategy.
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