Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
22 authors.
Khadija BanuDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-6680-2688
Mohammad Aslam KhanDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1855-1279
Sihan LiDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0005-6211-6847
Morgan Reynolds-GaglianoDepartment of Cell and Molecular Biology and Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0002-4830-3679
Xiaofei WangAnimal Resources Center, St. Jude Children's Research Hospital, Memphis, TN, USA.
Robert J MobleyDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2728-8206
Kelly R BarnettDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-9790-0352
Matthew M WielgoszVector Development and Production Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-3247-9488
Matthew BaulerVector Development and Production Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-1861-9971
Christopher WincekVector Development and Production Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kiran KodaliCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0854-1405
Wei WangCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Vishwajeeth PagalaCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anthony A HighCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2323-5649
Daniel PutnamDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-8080-775X
Rishi S KotechaLeukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.ORCID 0000-0003-1836-4075
Laurence C CheungLeukaemia Translational Research Laboratory, WA Kids Cancer Centre, The Kids Research Institute Australia, University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-6298-5288
Xiaotu MaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-6233-2145
Robert E ThromVector Development and Production Laboratory, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-9191-4742
Shondra M Pruett-MillerDepartment of Cell and Molecular Biology and Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-3793-585X
Daniel SavicDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-6693-0265
Samuel W BradyDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-5518-7800
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Cancer therapeutics frequently fail in clinical trials because of poor therapeutic index (efficacy-to-toxicity ratio). We systematically identified targets likely to have a good therapeutic index, revealing insulin receptor substrate 4 (IRS4) as a dependency in
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors. · full record | OpenQuestion