ArticleLangmuir : the ACS journal of surfaces and colloids2026
A Bio-Hybrid ZnO Nanoplatform Functionalized with Antimicrobial Peptide/Protein Enhances Multimodal Bacterial Eradication and Accelerated Wound Healing.
Article in Langmuir : the ACS journal of surfaces and colloids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The increasing prevalence of bacterial infections, along with the persistence of biofilms and impaired wound healing, underscores the urgent need for advanced antimicrobial strategies. In the current study, ZnO nanoparticles (NPs) were synthesized by the sol-gel method and functionalized with PEG to improve the colloidal stability and biocompatibility. The PEG-functionalized ZnO NPs were then conjugated with the antimicrobial peptide nisin and the enzyme lysozyme to obtain two distinct nanoconjugates: nisin-PEG-ZnO and lysozyme-PEG-ZnO. Extensive physicochemical analyses, including Fourier-transform infrared (FT-IR), ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), ζ-potential, dynamic light scattering (DLS), and thermogravimetric analysis (TGA), validated the successful synthesis of ZnO NPs and their efficient PEG-mediated surface functionalization. The antimicrobial potential of nanoconjugates against
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